Dec 25, 2024 · IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1. Among its related pathways are TGF-Beta Pathway and Akt Signaling.

We sought to provide a comprehensive analysis of the redundant and distinct roles of IL-4 and IL-13 in type 2 inflammation and report dupilumab mechanisms of action. Methods: Using primary cell assays and a mouse model of house dust mite-induced asthma, we compared IL-4 vs IL-13 vs IL-4Rα blockers.

Mar 6, 2020 · Interleukin (IL)-4 and IL-13 are well known for their key roles in type 2 immune responses, which result in resistance to helminth parasites and inactivation of toxins.

Jan 4, 2023 · Targeting interleukin 4 receptor alpha (IL-4Rα), an IL-4/IL-13 signalling axis, with dupilumab shows efficacy in AD. We investigated the importance of IL-4Rα signalling specifically on B and...

Feb 8, 2025 · Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.

Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various mechanisms through which receptor function is modulated.

This article reviews existing therapies targeting IL4, IL4R, or IL4/IL4R signaling, and recent findings guiding the creation of novel therapies that specifically inhibit the type II IL4R, while taking into consideration effects on immune cells within the tumor microenvironment.

Gene ID: 3566, updated on 8-Feb-2025. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 …

Feb 8, 2025 · Clinical resource with information about IL4R, A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci., A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study., and available tests.

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor.