2024年12月25日 · IL1RN (Interleukin 1 Receptor Antagonist) is a Protein Coding gene. Diseases associated with IL1RN include Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis and Microvascular Complications Of Diabetes 4. Among its related pathways are Interleukin-1 family signaling and IL-1 Family Signaling Pathways.

Interleukin-1 receptor antagonist (IL-1ra) is an endogenous immunomodulatory cytokine encoded by IL1RN on chromosome 2 that inhibits the actions of IL-1α and IL-1β [1, 2]. IL-1ra is secreted by cells of the immune system as well as a variety of other cell types; it is also considered to be an acute phase reactant and is secreted by the liver [3].

Authors demonstrated that methionine deprivation inhibited glioma cell proliferation via downregulating interleukin 1 receptor antagonist (IL1RN) both in vitro and in vivo, methionine deprivation or knocking down IL1RN induced glioma cell cycle arrest.

2023年4月1日 · IL1RA gene (IL1RN) carries polymorphisms in a variety of squamous cell carcinomas. IL1RA exhibits inhibitory effects on various squamous cell carcinomas. Inflammation, especially chronic inflammation, is closely linked to tumor development.

2022年6月21日 · IL-1α, IL-1β and IL-1RA are highly regulated inflammatory mediators involved in damage- and pathogen-associated molecular pattern (DAMPs and PAMPs), and cell death pathways. Patients with evidence...

2014年3月1日 · The IL1RN gene produces two forms of IL1RN: intracellular (icIL1RN) and secreted (sIL1RN) which are controlled by different promoter regions (Redlitz et al., 2004). Table of four IL1RN isoforms, showing the amino acid sequences and other protein characteristics.

Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival.

2024年6月14日 · The data suggest that the IL1RN pathway modulates the severity of coronavirus disease 2019 (COVID-19) via endogenous anti-inflammatory mechanisms. Keywords: IL1RN; SARS-CoV-2; genetic variation and mortality; inflammation.

2009年6月4日 · Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations of IL1RN, which encodes...

2025年2月8日 · Title: Exosome microRNA-125a-5p derived from epithelium promotes M1 macrophage polarization by targeting IL1RN in chronic obstructive pulmonary disease.