Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities.

The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth. Studies suggest that insulin-like growth factor 2 promotes the growth and division (proliferation) of cells in many different tissues.

IGF2 (insulin-like growth factor 2) is a member of the insulin-like growth factor family that is involved in cell proliferation and differentiation. You might find these chapters and articles relevant to this topic. The insulin-like growth factor (IGF) system is relevant for meningioma tumorigenesis, but the exact mechanisms are unknown.

Non-islet cell tumour hypoglycemia (NICTH), typically mediated by insulin-like growth factor 2 (IGF-2), is a rare but highly morbid paraneoplastic syndrome associated with tumours of mesenchymal or epithelial origin.

IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development. IGF-II is also found to be overexpressed in several cancer types, promoting growth and survival.

Effective July 25, 2024: This test is temporarily unavailable due to reagent supply. The downtime is expected to be >30 days. An alternate test option is not available. See test notification here. Insulin-like Growth Factor 2 (IGF-2)

In adults, IGF-II plays important tissue-specific roles, including the maintenance of stem cell populations. Although the IGF-IR is closely related to the IR it has distinct physiological roles both on the cell surface and in the nucleus.

2024年12月25日 · IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2025年2月8日 · IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review.

2022年6月10日 · In the 30 years since the first report of parental imprinting in insulin-like growth factor 2 (Igf2) knockout mouse models, we have learnt much about the structure of this protein, its role and regulation. Indeed, many animal and human studies involving innovative techniques have shed light on the complex regulation of IGF2 expression.