Hydroxyprostaglandin dehydrogenase 15- (NAD) (the HUGO -approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase [NAD+], is an enzyme that in humans is encoded by the HPGD gene. [5][6] In melanocytic cells HPGD gene expression may be regulated by MITF. [7]

Dec 25, 2024 · HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) and Fatty acid metabolism.

Intestinal tumors in ApcMin/+ mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D 2 (PGD 2). We characterized naturally occurring HPGDS isoenzymes, to see if HPGDS variation is …

Prostaglandins (PGs), crucial mediators of parturition, are inactivated by 15-hydroxyprostaglandin dehydrogenase (HPGD) via oxidation. Human placentas from preterm birth (PTB) display reduced HPGD levels and hypomorphic Hpgd expression in mice causes PTB.

Mar 4, 2010 · 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. The anabolic pathways of prostaglandins are well-characterized, especially with respect to regulation of the cyclooxygenase (COX) enzymes.

Nov 5, 2021 · Familial erythrocytosis (congenital erythrocytosis, FE), is a rare congenital disorder defined by elevated hemoglobin and hematocrit, with different genetic background. Clinically, FE is difficult to distinguish from polycythemia vera（PV）.

The data indicate that HPGD-mediated suppression is a tissue- and context-dependent suppressive mechanism used by Regulatory T cells to maintain adipose tissue homeostasis. We describe for the first time an association between maternal smoking and HPGD expression.

2 days ago · Cervical cancer is the second most common malignancy in women worldwide. According to statistics of the Global Cancer Observatory (GLOBOCAN) 2020, there were an estimated 604 127 cervical cancer cases, accounting for about 6.5% of all new cancer cases in women, and approximately 84% occur in low- and middle-income countries. 1,2 At present, …

Intestinal tumors in Apc (Min/+) mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D (2) (PGD (2)). We characterized naturally occurring HPGDS isoenzymes, to see if HPGDS variation is …

Nov 26, 2019 · To test the hypothesis that 15-PGDH-mediated PG metabolism is essential for pregnancy maintenance and normal labor timing, we generated and analyzed pregnancy in 15-HPGD knockout mice (Hpgd...