Hydroxyprostaglandin dehydrogenase 15- (NAD) (the HUGO -approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase [NAD+], is an enzyme that in humans is encoded by the HPGD gene. [5][6] In melanocytic cells HPGD gene expression may be regulated by MITF. [7]

2024年12月25日 · HPGD (15-Hydroxyprostaglandin Dehydrogenase) is a Protein Coding gene. Diseases associated with HPGD include Digital Clubbing, Isolated Congenital and Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) and Fatty acid metabolism.

5 天之前 · Zhen He, Sheng-Ming Dai; Inflammatory polyarthritis unmasking primary hypertrophic osteoarthropathy: spotlight on compound heterozygous HPGD mutations, QJM

Prostaglandins (PGs), crucial mediators of parturition, are inactivated by 15-hydroxyprostaglandin dehydrogenase (HPGD) via oxidation. Human placentas from preterm birth (PTB) display reduced HPGD levels and hypomorphic Hpgd expression in mice causes PTB.

2010年3月4日 · 15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. The anabolic pathways of prostaglandins are well-characterized, especially with respect to regulation of the cyclooxygenase (COX) enzymes.

2008年5月25日 · By autozygosity methods, we mapped PHO to chromosome 4q33–q34 and identified mutations in HPGD, encoding 15-hydroxyprostaglandin dehydrogenase, the main enzyme of prostaglandin degradation....

Hematopoietic prostaglandin D 2 synthase (hPGD 2 S) metabolizes cyclooxygenase (COX)-derived PGH 2 to PGD 2 and 15-deoxyΔ 12–14 PGJ 2 (15d-PGJ 2). Unlike COX, the role of hPGD 2 S in host defense is ambiguous.

15-hydroxyprostaglandin dehydrogenase (15-PGDH; HPGD) is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation. The anabolic pathways of prostaglandins are well-characterized, especially with respect to regulation of the cyclooxygenase (COX) enzymes.

Official gene symbol, which is typically a short form of the gene name, according to HGNC. Assigned HPA protein class (es) for the encoded protein (s). Number of protein-coding transcripts from the gene as defined by Ensembl.

Synonym (s): 15-hydroxyprostaglandin dehydrogenase (NAD (+)), SDR36C1, short chain dehydrogenase/reductase family 36C, member 1. Previous symbol (s) and name (s): hydroxyprostaglandin dehydrogenase 15- (NAD) Type: gene with protein product. Chromosomal location: 4q34.1. OMIM: 601688. HGNC: 5154. UniProtKB: P15428. Genatlas: HPGD. …