2024年12月25日 · HOXD10 (Homeobox D10) is a Protein Coding gene. Diseases associated with HOXD10 include Vertical Talus, Congenital and Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding.

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. [5] This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a …

2014年7月10日 · HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10...

High expression of HOXD10 is associated with laryngeal squamous cell carcinoma. Low HOXD10 promotes migration and invasion in gastric cancer. These results suggested that HOXD10 may be a putative suppressor gene and can act as a prognostic marker and potentially a novel therapeutic target for cholangiocellular carcinoma.

2024年9月19日 · Homeobox D10, a tumor suppressor, inhibits the proliferation and migration of esophageal squamous cell carcinoma. Zhang J, Liu S, Zhang D, Ma Z, Sun LZhang J, et al. J Cell Biochem, 2019 Aug. PMID 30938888. Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway.

2014年4月7日 · Expression of MIR7-1 or HOXD10 reduced expression of EGFR (131550) and IRS1 (147545) proteins in human cell lines. In 14 members of a family of Italian extraction with isolated congenital vertical talus (CVT; 192950), Shrimpton et al. (2004) identified a heterozygous missense mutation in the HOXD10 gene (M319K; 142984.0001).

关于 hoxd10 Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,116,778-176,119,937 (from NCBI) This gene has 3 transcripts (splice variants), 208 orthologues, 42 paralogues and is associated with 3 phenotypes.

View mouse Hoxd10 Chr2:74522268-74525449 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

2021年10月31日 · HOXD10 Is Frequently Methylated in Colorectal Cancer and Its Hypermethylation Correlates with Advanced Disease and Metastasis. To investigate the role of HOXD10 methylation in CRC, we first evaluated HOXD10 methylation in tumor and normal tissues from TCGA database and our cohort.

HOX gene expression is altered in many cancers; previous microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10 expression was assessed by qPCR and immunoblotting in vitro and ...