Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene. [5][6] This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

2024年12月25日 · HOXC10 (Homeobox C10) is a Protein Coding gene. Diseases associated with HOXC10 include Immunodeficiency 54. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

Hoxc10, an embryonic layer-specific genes, regulates cartilage formation during bone healing. Mechanistically, we observed Hoxc10 retention in co-cultured femoral BMSCs. Knocking out Hoxc10 narrows the bone gap and reduces cartilage formation.

2021年5月24日 · HOXC10 is an important transcription factor that can activate several oncogenic pathways by regulating various target molecules such as ERK, AKT, p65, and epithelial mesenchymal transition-related genes. HOXC10 also induces drug resistance in cancers by promoting the DNA repair pathway.

哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。 该基因是位于 12 号染色体簇中的几个同源盒 HOXC 基因之一。 蛋白质水平在细胞分化和增殖过程中受到控制，这可能表明该蛋白质在起源激活中起作用。 [RefSeq 提供，2008 年 7 月] This gene belongs to the homeobox family of genes.

2021年5月25日 · HOXC10 is an important transcription factor that can activate several oncogenic pathways by regulating various target molecules such as ERK, AKT, p65, and epithelial mesenchymal transition-related genes. HOXC10 also induces drug resistance in cancers by promoting the DNA repair pathway.

HOXC10 indicates poor survival outcome in gastric cancer and promotes G1/S cell cycle transition through transcriptional repression of p21. [The effect of HOXC10 gene on biological behaviors of glioma cells and mechanism in tumor microenvironment].

2019年5月17日 · Homeodomain-containing gene 10 (HOXC10) is a member of the homeobox transcription factors that plays an important role in the development of multicellular organisms. HOXC10 is overexpressed in a variety of human cancers, and recent studies have revealed that HOXC10 is upregulated in gastric cancer as well.

Gastric cancer is one of the most common malignant tumors in the world. Recently reported, aberrations in HoxC10 expression was implicated in the proliferation, apoptosis, invasion and metastasis...

HOXC10 is an important transcription factor that can activate several oncogenic pathways by regulating various target molecules such as ERK, AKT, p65, and epithelial mesenchymal transition-related genes. HOXC10 also induces drug resistance in …