The seven decades of research on the mechanism of HMG-CoA Reductase (HMGR) provided a detailed reaction pathway for what is one of the most biomedically important and mechanistically most complex enzymes. HMGR is the target of statins that are ...

The human hmgr gene that encodes the single human HMG-CoA reductase is located on chromosome 5, map location 5q13.3-5q14, and is over 24.8 kilobases (kb) long.

2024年12月25日 · HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 28 and Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 3. Among its related pathways are superpathway of cholesterol biosynthesis and Metabolism of steroids.

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure ...

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

Hydroxymethylglutaryl-CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols representing one class of major importance.

2013年11月19日 · HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide. More recent research indicates that HMGR could be a useful target in the development of antimicrobial agents.

2019年10月1日 · As one of the rate-limiting enzymes in the mevalonic acid (MVA) pathway of TTL biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the 3-hydroxy-3-methylglutaryl...

NORK in legumes encodes a receptor-like kinase that is required for Nod factor signaling and root nodule development. Using Medicago truncatula NORK as bait in a yeast two-hybrid assay, we identified 3-hydroxy-3-methylglutaryl CoA reductase 1 …

2011年10月1日 · HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of hypocholesterolemic drug therapy. HMGR activity is tightly regulated to ensure maintenance of lipid homeostasis, disruption of which is a major cause of human morbidity and mortality.

2001年5月11日 · HMG-CoA (3-hydroxy-3-methylglutaryl–coenzyme A) reductase (HMGR) catalyzes the committed step in cholesterol biosynthesis. Statins are HMGR inhibitors with inhibition constant values in the nanomol...

3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is controlled through synthesis, degradation and phosphorylation to maintain the concentration of mevalonate-derived products.

Three-dimensional structures of the catalytic domain of HMG-CoA reductases from humans and from the bacterium Pseudomonas mevalonii, in conjunction with site-directed mutagenesis studies, have revealed details of the mechanism of catalysis.

2013年7月30日 · HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide. More recent research indicates that HMGR could be a useful target in the development of antimicrobial agents.

2004年11月1日 · The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is the rate-limiting step in the synthesis of cholesterol and other isoprenoids.

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase; HMGR) is the key enzyme of the MVA pathway. The HMGR-catalyzed reaction produces mevalonic acid from HMG-CoA by reduction with NADPH (Figure 1). Statins, a class of top-selling drugs for lowering cholesterol, target HMGR [31].

2025年3月5日 · 3-Hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGR, E.C. 1.1.1.34), which catalyzes the irreversible action of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to generate MVA, is the first rate-limiting enzyme upstream of the MVA metabolic pathway, and an important regulatory point for the synthesis of terpenoids (Bach, 1986; Fig ...

3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is a transmembrane glycoprotein, located on the endoplasmic reticulum. 1 This enzyme catalyzes the four-electron reduction of HMG-CoA to coenzyme A and mevalonate, which is the ratelimiting step in sterol biosynthesis. 2 The activity of HMGR is controlled through synthesis, degradation, and ...

In the mevalonic acid (MVA) pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is considered the first rate-limiting enzyme in isoprenoid biosynthesis. In this study, we cloned a full-length cDNA from Populus trichocarpa with an open reading frame of 1,734 bp.

2025年2月17日 · Rosa rugosa is an excellent aromatic plant species valued for both essential oil extraction and ornamental applications. This study aimed to evaluate its adaptive responses, bioaccumulation capacity, and production quality under cadmium (Cd) stress, providing insights for phytoremediation and sustainable agriculture.