The seven decades of research on the mechanism of HMG-CoA Reductase (HMGR) provided a detailed reaction pathway for what is one of the most biomedically important and …

The human hmgr gene that encodes the single human HMG-CoA reductase is located on chromosome 5, map location 5q13.3-5q14, and is over 24.8 kilobases (kb) long.

2024年12月25日 · HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Muscular Dystrophy, Limb-Girdle, Autosomal …

HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from …

Hydroxymethylglutaryl-CoA reductase (HMGR) regulates the synthesis of mevalonic acid (MVA), the precursor of the myriad of isoprenoid compounds functional in plant cells, with phytosterols …

2013年11月19日 · HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide. More recent research indicates that HMGR …

2019年10月1日 · As one of the rate-limiting enzymes in the mevalonic acid (MVA) pathway of TTL biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) catalyzes the 3 …

NORK in legumes encodes a receptor-like kinase that is required for Nod factor signaling and root nodule development. Using Medicago truncatula NORK as bait in a yeast two-hybrid assay, …

2011年10月1日 · HMG-CoA reductase (HMGR), a highly conserved, membrane-bound enzyme, catalyzes a rate-limiting step in sterol and isoprenoid biosynthesis and is the primary target of …

2001年5月11日 · HMG-CoA (3-hydroxy-3-methylglutaryl–coenzyme A) reductase (HMGR) catalyzes the committed step in cholesterol biosynthesis. Statins are HMGR inhibitors with …

3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) catalyzes the formation of mevalonate, the committed step in the biosynthesis of sterols and isoprenoids. The activity of HMGR is …

Three-dimensional structures of the catalytic domain of HMG-CoA reductases from humans and from the bacterium Pseudomonas mevalonii, in conjunction with site-directed mutagenesis …

2013年7月30日 · HMG-CoA reductase (HMGR) is the target of statins, cholesterol-lowering drugs prescribed to millions of patients worldwide. More recent research indicates that HMGR could …

2004年11月1日 · The enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the conversion of HMG-CoA to mevalonate, a four-electron oxidoreduction that is …

HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase; HMGR) is the key enzyme of the MVA pathway. The HMGR-catalyzed reaction produces mevalonic acid from HMG-CoA by …

2025年3月5日 · 3-Hydroxy-3-methylglutaryl monoacyl-coenzyme A reductase (HMGR, E.C. 1.1.1.34), which catalyzes the irreversible action of 3-hydroxy-3-methylglutaryl coenzyme A …

3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is a transmembrane glycoprotein, located on the endoplasmic reticulum. 1 This enzyme catalyzes the four-electron reduction of HMG-CoA …

In the mevalonic acid (MVA) pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is considered the first rate-limiting enzyme in isoprenoid biosynthesis. In this study, we cloned a …

2025年2月17日 · Rosa rugosa is an excellent aromatic plant species valued for both essential oil extraction and ornamental applications. This study aimed to evaluate its adaptive responses, …