Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. [5] [6] [7] …

Dec 25, 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its …

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic …

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the …

Feb 15, 2008 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further …

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced …

Feb 29, 2004 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 …

HIF1A driven transcriptional response in hypoxia depends on epigenetic control at DNA methylation status of gene regulatory regions. Furthermore, low oxygen levels generate HIF1A …

Jun 8, 2015 · 1a (HIF1a), a transcription factor (TF) activated by low oxygen, mediates a pro-proliferative response during cardiac develop-ment. In well-perfused tissues, HIF1a subunits …

We hypothesized that intermittent hypoxia (IH) modeling obstructive sleep apnea would worsen hepatic steatosis and fibrosis in murine NAFLD, via HIF-1. Mice with hepatocyte-specific …