2024年12月25日 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its related pathways are Signaling by PTK6 and Autodegradation of the E3 ubiquitin ligase COP1.

2008年2月15日 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further diversity is...

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic approaches targeting this important pathway. 1. The role of HIF-1 α pathway in cellular adaptation to hypoxic stress.

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the expression of many genes in the organism and is closely associated with the biological behavior of malignant tumors. 1,2 Importantly, HIF-1α is commonly highly expres...

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer.

The p300/CBP-associated factor (PCAF) can acetylate K674 of HIF1A leading to increased HIF1A protein levels and binding of the transcriptional co-activator p300, and to enhanced transactivation of certain HIF1A target genes (Lim et al, 2010).

2024年7月23日 · Here, we investigated differential but complementary roles of hypoxia-inducible factor (HIF)-1α and HIF-2α in regulating bone remodeling. Using RNA-seq analysis, we identified that specific genes...

2004年2月29日 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one of three subunits (HIF-1alpha, HIF-2alpha or HIF-3alpha).

2023年3月30日 · In the intra-tumoral hypoxic environment, HIF-1α is highly expressed and contributes to the malignant progression of tumors, which in turn results in a poor prognosis in patients.

2023年11月13日 · Under hypoxic conditions, hypoxia-inducible factor 1 α (HIF1α) is a major regulator that promotes tumor development and increases glycolysis. The expression of HIF1α increases glucose...