2024年12月25日 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Pheochromocytoma and Retinal Ischemia. Among its …

2008年2月15日 · In keeping with the complexity of the hypoxic response, three principal isoforms of HIF- α exist (HIF-1 α, HIF-2 α and HIF-3 α). All are encoded by distinct gene loci and further …

Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1 α in cancer and recent therapeutic …

Recently, it has been identified that hypoxia-inducible factor-1 alpha (HIF-1α) is a major transcriptional regulatory factor that responds to hypoxic environments and modulates the …

HIF1A promotes miR-210/miR-424 transcription to modulate the angiogenesis in HUVECs and HDMECs via sFLT1 under hypoxic stress. HIF-1alpha and Nrf2 regulates hypoxia induced …

The p300/CBP-associated factor (PCAF) can acetylate K674 of HIF1A leading to increased HIF1A protein levels and binding of the transcriptional co-activator p300, and to enhanced …

2024年7月23日 · Here, we investigated differential but complementary roles of hypoxia-inducible factor (HIF)-1α and HIF-2α in regulating bone remodeling. Using RNA-seq analysis, we …

2004年2月29日 · Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian …

2023年3月30日 · In the intra-tumoral hypoxic environment, HIF-1α is highly expressed and contributes to the malignant progression of tumors, which in turn results in a poor prognosis in …

2023年11月13日 · Under hypoxic conditions, hypoxia-inducible factor 1 α (HIF1α) is a major regulator that promotes tumor development and increases glycolysis. The expression of HIF1α …