HIF1α and HIF2α are considered to be the canonical inducible activators of the response to hypoxia while HIF3α is less well understood. HIF1α is widely expressed, while HIF2α is …

Sep 5, 2024 · Targeting HIF-2α holds great promise for effectively addressing solid tumors associated with aberrant oxygen-sensing pathways and hypoxia mechanisms, offering broad …

Hypoxia-inducible factor-2 alpha (HIF-2⍺) is a transcription factor that induces target genes responsible for the hypoxic stress response. Hypoxia enhances cancer cell resistance to …

The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors – HIF-1α and HIF-2α. While these proteins are highly homologous, increasing evidence …

Mar 4, 2023 · Here we briefly recapitulate the molecular rationale for HIF2α blockade in tumors and review available preclinical and clinical data, elaborating on mutations that might be …

Jan 18, 2025 · HIF-1 and HIF-2 are well known and widely described. Although these proteins share a high degree of homology, HIF-1 and HIF-2 have non-redundant roles in cancer. In this …

Park S.-K., et al. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1a (HIF-1a): role of cytoplasmic trapping of HIF-2a.

Nov 5, 2020 · Mice with a neuro-specific knockout of Hif-2α showed a reduction of pyramidal neurons in the retrosplenial cortex (RSC), a brain region responsible for a range of cognitive …

Mar 1, 2001 · Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia. Because the efficacy of photodynamic therapy (PDT) is …

Jul 18, 2023 · HIF-1a and HIF-2a upstream and downstream pathways promoting cancer. HIF-1a expression varies with oxygen level in the cellular environment while HIF-2a is constitutively …