Jan 2, 2025 · Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. Induced Hey2 expression in zebrafish...

Dec 25, 2024 · HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include Familial Thoracic Aortic Aneurysm And Aortic Dissection and Tricuspid Atresia.

Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene. [5][6]

通过透射电镜检测分析，Hey2心肌过表达引起线粒体数目减少、膜和嵴等超微结构异常，损害线粒体膜电位（MMP），并伴随ROS升高，导致心肌细胞凋亡（图1）。

2025年1月2日，华东师范大学 钟涛 教授研究合作团队在 Nature Communications 期刊在线发表题为 The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis 的研究论文。 该研究应用斑马鱼、小鼠、哺乳动物及人类心肌细胞为模型， 发现转录抑制因子HEY2与HDAC1结合，通过组蛋白去乙酰化和染色质可及性重塑，控制能量转录共激活因子及脂肪酸氧化酶的表达，将线粒体氧化呼吸和代谢限制在合理水平，从而实现心脏 …

Jan 8, 2025 · “The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis”发表于 Nature Communications （IF 14.7），研究发现 HEY2 在扩张型心肌病患者心脏中上调，其在心肌细胞中的异常表达会影响 线粒体呼吸，进而影响心脏功能。

Jan 2, 2025 · Here, we report that HEY2 (a Hairy/Enhancer-of-split-related transcriptional repressor) is upregulated in hearts of patients with dilated cardiomyopathy. Induced Hey2 expression in zebrafish hearts or mammalian cardiomyocytes impairs mitochondrial respiration, accompanied by elevated ROS, resulting in cardiomyocyte apoptosis and heart failure.

Feb 8, 2018 · To determine the expression pattern and the regulation of Hey2, we used novel methods including RNAscope and a Hey2CreERT2 knockin line to precisely determine the spatiotemporal expression...

Apr 10, 2018 · Gene expression profiling and ChIP-seq identifies HEY2, a NOTCH-dependent bHLH class transcription factor 15, as a potential downstream mediator of NKX2-5. Furthermore, genetic rescue experiments...

Feb 20, 2025 · Data indicate that culture abrogated differential gene expression in part due to gradual loss of canonical Notch activity and HEY2 expression. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death