Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a protein that in humans is encoded by the HEY2 gene. [5][6]

2025年1月2日 · Induced Hey2 expression in zebrafish hearts or mammalian cardiomyocytes impairs mitochondrial respiration, accompanied by elevated ROS, resulting in cardiomyocyte apoptosis and heart failure.

2024年12月25日 · HEY2 (Hes Related Family BHLH Transcription Factor With YRPW Motif 2) is a Protein Coding gene. Diseases associated with HEY2 include Familial Thoracic Aortic Aneurysm And Aortic Dissection and Tricuspid Atresia .

2018年4月10日 · Gene expression profiling and ChIP-seq identifies HEY2, a NOTCH-dependent bHLH class transcription factor 15, as a potential downstream mediator of NKX2-5. Furthermore, genetic rescue experiments...

2025年1月2日 · Knockdown of Hey2 in adult mouse hearts protects against doxorubicin-induced cardiac dysfunction. These studies reveal an evolutionarily conserved HEY2/HDAC1-Ppargc1/Cpt transcriptional module that controls energy metabolism to preserve cardiac function.

2018年2月8日 · We found that Hey2 is expressed in the endocardial cells of the atrioventricular canal and the outflow tract, as well as at the base of trabeculae, in addition to the reported expression in the...

2025年2月20日 · Genetic variation of HEY2 is associated with Brugada syndrome through alteration of ion channel expression in the cardiac ventricular wall. Individuals with HEY2 duplications should be screened for congenital heart defects.

2017年6月21日 · The HEY2 locus harbors common variants with a moderate effect size (odds ratio of 1.6 per risk allele) 2 and should be regarded as a modifier of BrS risk among other genetic and acquired risk factors.

To determine the expression pattern and the regulation of Hey2, we used novel methods including RNAscope and a Hey2CreERT2 knockin line to precisely determine the spatiotemporal expression pattern and level of Hey2 during cardiac development.

HEY2 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in the developing mammalian heart and brain. In humans, nonsynonymous mutations in HEY2 have been described in patients with atrial ventricular septal defects, and a subset of individuals with chromosomal deletions involving HEY2 have cardiac defects and ...