HES1 influences the maintenance of certain stem cells and progenitor cells. Specifically, HES1 influences the timing of differentiation by repressing bHLH activators, and determines binary cell fate. HES1 has been shown to play a large role in both the nervous, and digestive systems.

Dec 25, 2024 · HES1 (Hes Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with HES1 include Alagille Syndrome 1 and Strawberry Gallbladder. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Autodegradation of the E3 ubiquitin ligase COP1.

Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1 after birth.

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

Hes1, a canonical Notch target and transcriptional repressor, is responsible for sustaining IKK activation in T-ALL. Hes1 exerts its effects by repressing the deubiquitinase CYLD, a negative IKK complex regulator.

Hes1 Regulates Hedgehog Signaling via Direct Binding to Gli1. As previous work has suggested the potential for crosstalk between the Notch and Hedgehog signaling cascades , we focused on the upregulation of Hedgehog signaling in response to MRK-003.

Hairy and enhancer of split (HES1), a transcription factor whose expression is initiated by the Notch signaling pathway, is a repressor of cell cycle inhibitors. We hypothesize that with the loss of Hes1, pituitary progenitors are no longer maintained in a proliferative state, choosing instead to exit the cell cycle.

In this review, we focus on how a dynamic gene, Hes1, is involved in neurogenesis with the view of its regulation and functional implications. Initially, we have reviewed the immense functional significance drawn by this maestro during neural development in a context-dependent manner.

Oct 2, 2014 · Hes1 inhibits proliferation and differentiation of neural precursor cells. Hes1 may represent a negative regulator of adult neurogenesis post-TBI. Hes1 knockdown improves cognitive function of adult mouse following injury.

Jan 30, 2014 · HES1 belongs to a family of basic helix-loop-helix (bHLH) proteins that are essential for neurogenesis, myogenesis, hematopoiesis, and sex determination. HES1 is a transcriptional repressor for a number of genes, but it can also function as a transcriptional activator (Yan et al., 2002).

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.

Aug 1, 2016 · HES1 is regulated by the NOTCH signalling pathway as well as the wnt and hedgehog pathways. HES1 plays an important role in T cell development and cancer. HES1 represents a potent therapeutic target in cancer and leukaemia.

A transcriptional regulator, Hes1, plays crucial roles in the control of differentiation and proliferation of neuronal, endocrine, and T-lymphocyte progenitors during development. Mechanisms for the regulation of cell proliferation by Hes1, however, ...

The transcriptional repressor Hairy Enhancer of Split 1 (HES1) plays an essential role in the development of many organs by promoting the maintenance of stem/progenitor cells, controlling the reversibility of cellular quiescence, and regulating both cell fate decisions.

HES1 is a transcriptional repressor that inhibits its own transcription and causes HES1 to oscillate with a 2–3h periodicity in NSCs. In turn, the proneural gene Ascl1, which is a downstream target of HES1 (Chen et al., 1997), also oscillates with a similar period and it is inversely correlated with HES1 expression (Im-ayoshi et al., 2013).

Mar 10, 2011 · We report that HES1 regulates proapoptotic signals by the novel interacting protein Poly ADP-Ribose Polymerase1 (PARP1) in a cell type–specific manner. Interaction of HES1 with PARP1 inhibits HES1 function, induces PARP1 activation, and results in PARP1 cleavage in B-ALL.

May 30, 2023 · Here, we show that oscillatory Hes1 expression down-regulates the expression of the cyclin-dependent kinase inhibitor p21 (Cdkn1a), which delays cell-cycle progression, and thereby activates the proliferation of mouse neural stem cells (NSCs).

Notch target gene Hes1 is regulated by the transforming growth factor-β/bone morphogenetic protein signaling pathway in hepatic stellate cell-T6 cells. A: Western blot analysis of Hes1 expression in cells transfected with pcDNA3.1-NICD1.

Jan 1, 2000 · Hes1 is one of the basic helix-loop-helix transcription factors that regulate mammalian CNS development, and its loss- and gain-of-function phenotypes indicate that it negatively regulates neuronal differentiation.

Feb 26, 2020 · To examine the effect of altered oscillatory dynamics of Hes1, we generated two types of Hes1 knock-in mice, a shortened (type-1) and an elongated (type-2) Hes1 gene, and examined their phenotypes focusing on neural development.