her4有七种已知配体，包括nrg1-4，hb-egf，btc，epr，her4与配体结合后被激活，通过mapk和pi3k-akt信号通路向下游传递信号。 HER4在人体许多组织中都有表达，对心血管、神经和内分泌系统的正常发育至关重要，有研究表明HER4的过表达与癌症的发展有关，也有研究表明 ...

Dec 25, 2024 · ErbB4 (HER4) is one of the four members in the EGFR subfamily of receptor tyrosine kinases. Ligands include EGF, epiregulin, betacellulin and the neuregulins (Sundvall et. al.). Of these, NRG3 and NRG4 exclusively bind HER4 (Hynes et. al.).

Dec 5, 2021 · HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. HER4 is commonly expressed in many hum …

EGFR（Epidermal Growth Factor Receptor）是 上皮生长因子 （EGF） 细胞增殖 和信号传导的受体。 EGFR属于ErbB 受体家族 的一种，该家族包括EGFR (ErbB-1),HER2/c-neu(ErbB-2),Her 3(ErbB-3) 和Her 4(ErbB-4)。 EGFR也被称作HER1、ErbB1，突变或过表达一般会引发肿瘤。 EGFR是一种糖蛋白，属于酪氨酸激酶型受体，细胞膜贯通，分子量170KDa。 EGFR位于细胞膜表面，靠与配体结合来激活，包括EGF和TGFα（transforming growth factor α）。 激活 …

HER4 is known for its positive role in tumor progression, including the acceleration of human breast cancer cell growth [5, 6] and the induction of mouse mammary carcinoma formation . HER4 can also transform in vitro and influence carcinomas in immune-deficient mice by interacting with other EGFR family members [8, 9].

her4 是神经调节蛋白和 egf 家族成员的重要酪氨酸蛋白激酶受体，可指导心脏、中枢神经系统和乳腺发育。它对于心肌分化、出生后心肌细胞增殖、神经嵴细胞迁移、轴突引导和乳腺功能至关重要。

Dec 5, 2021 · her4 是一种受体酪氨酸激酶，是心血管、神经和内分泌系统（尤其是乳腺）等正常身体系统进化所必需的。它通过配体结合被激活并激活 mapk 和 pi3k/akt 通路。 her4 通常在许多人体组织中表达，包括成人和胎儿。了解 her4 在许多疾病治疗中的作用非常重要。

Thus, HER4 can mediate antiproliferative and differentiative signals in human breast cancer cells. Activation of HER4 and HER2 has been associated with a range of responses, including growth stimulation and suppression, as well as stimulation of expression of differentiation markers.

Nov 22, 2016 · Cytoplasmic HER4 was more effective than nuclear HER4 (HR = 0.74, CI: 0.60-0.92, P = 0.007, fixed effects) for predicting RFS. HER4 was also found to be a favorable prognostic marker for overall survival (OS) among patients with non-TNBC in the subgroup analysis (Luminal: HR = 0.71, CI: 0.52-0.95, P = 0.023, fixed effects; HER2-positive: HR = 0 ...

Jan 1, 2021 · In this study, we identified a critical role of Her4 in rewiring cancer metabolism toward tumor-promoting metabolic processes, including increased glycolysis, glutaminolysis, mitochondrial biogenesis, and oxidative phosphorylation, which may in …