HAS2 is a member of the vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

2024年12月25日 · HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, …

HAS2 是新发现的编码假定乙酰透明质酸合酶的脊椎动物基因家族的成员，其氨基酸序列与非洲爪蟾的糖胺聚糖合成酶 (DG42) 以及人和鼠透明质酸合酶 1 具有显着同源性。[RefSeq 提供，2008 年 7 月]

Our study provides evidence that HAS2 actively synthesizes HA in HSCs and that it promotes HSC activation and liver fibrosis through Notch1. Targeted HA inhibition may have potential to be an effective therapy for liver fibrosis.

2023年8月23日 · Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation ...

HAS2 and HAS3 were the only hyaluronan synthases detected, the expression of which was almost similar in NPs and NM. HAS2 has been proposed to be a target for therapeutic intervention in cancer. Our findings suggested a possible antagonistic role of androgen receptor (AR) pathway on HAS2 function.

In this work, we showed that the level of hyaluronic acid synthase 2 (HAS2) was positively correlated with the malignant phenotype of breast cancer cells. Notably, the increased expression of HAS2 promoted the invasive and migratory abilities of luminal breast cancer cells in vitro, followed by a reduced expression of E-cadherin, β-catenin ...

2021年5月5日 · Hyaluronic acid synthase 2 (HAS2), giving rise to high-molecular-weight hyaluronan (HA) synthesis enriched in ECM [4, 5], is identified to play an important role in cancer cell malignancy and metastasis [6, 7].

2016年12月6日 · HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, …

The human hyaluronan synthase 2 (HAS2) gene encodes for an enzyme making hyaluronan, altered concentrations of which are associated with many pathological situations including wounding, several inflammatory conditions, and malignant tumors.