Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G q /G 11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, [4][5] that in humans is located on the X chromosome.

Dec 25, 2024 · HTR2C (5-Hydroxytryptamine Receptor 2C) is a Protein Coding gene. Diseases associated with HTR2C include Major Depressive Disorder and Anxiety. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Dec 19, 2022 · Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT 2C R (HTR2C) in 19 unrelated...

Mar 8, 2025 · In addition, your package will include a detailed data report in both TSV and JSONL formats. This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin.

Jun 28, 2024 · Here, we investigate the role of 5-HT 2C receptor (5-HT 2C R) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons.

Aug 13, 2018 · Here we genetically manipulate a subset of excitatory neurons expressing the serotonin receptor 2c (Htr2c) in the ventral hippocampus.

Dec 10, 2024 · Clinical resource with information about HTR2C, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Jan 1, 2018 · The 5-hydroxytryptamine-type 2C receptor (5-HT2C, previously 5-HT1C) is one of the 14 G protein-coupled receptor subtypes activated by serotonin. 5-HT2C receptors are involved in a large variety of physiological functions such as nociception, motor behavior, endocrine secretion, thermoregulation, modulation of appetite, and the control of exchan...

Jul 21, 2021 · The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, including feeding and glucose metabolism.

Apr 2, 2012 · Although HTR2C has been implicated in genetic studies of human behavioural abnormalities, many of these have focussed on using well described polymorphic markers, either singly or as haplotypes. Results are contradictory, and currently the role of this specific receptor remains inconclusive.