
5-HT2C receptor - Wikipedia
Like all 5-HT2 receptors, it is a G protein-coupled receptor (GPCR) that is coupled to G q /G 11 and mediates excitatory neurotransmission. HTR2C denotes the human gene encoding for the receptor, [4][5] that in humans is located on the X chromosome.
HTR2C Gene - GeneCards | 5HT2C Protein | 5HT2C Antibody
2024年12月25日 · HTR2C (5-Hydroxytryptamine Receptor 2C) is a Protein Coding gene. Diseases associated with HTR2C include Major Depressive Disorder and Anxiety. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).
Human loss-of-function variants in the serotonin 2C receptor
2022年12月19日 · Using exome sequencing of 2,548 people with severe obesity and 1,117 control individuals without obesity, we identified 13 rare variants in the gene encoding 5-HT 2C R (HTR2C) in 19 unrelated...
HTR2C 5-hydroxytryptamine receptor 2C [ Homo sapiens (human) ]
2025年3月8日 · Demonstrated that a 5-HT2AR:5-HT2CR interaction occurs in cultured cells using three complementary biophysical techniques with increasing spatial resolution. Findings indicate these receptors form a close biophysical interaction within 10 nm in living cells.
Serotonin receptor 2c-expressing cells in the ventral CA1 control ...
2018年8月13日 · Here we genetically manipulate a subset of excitatory neurons expressing the serotonin receptor 2c (Htr2c) in the ventral hippocampus.
Neural circuits expressing the serotonin 2C receptor regulate
2024年6月28日 · Here, we investigate the role of 5-HT 2C receptor (5-HT 2C R) in regulating memory. Transgenic mice expressing a humanized HTR2C mutation exhibit impaired plasticity of hippocampal ventral CA1 (vCA1) neurons and reduced memory. Further, 5-HT neurons project to and synapse onto vCA1 neurons.
UniProt
HTR2C is coupled to G (q)/G 11 G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca 2+ ions from intracellular stores, respectively (PubMed: 18703043, PubMed: 29398112).
HTR2C 5-hydroxytryptamine receptor 2C - NIH Genetic Testing …
2024年12月10日 · Clinical resource with information about HTR2C, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.
Central 5-HTR2C in the Control of Metabolic Homeostasis
2021年7月21日 · The 5-hydroxytryptamine 2C receptor (5-HTR2C) is a class G protein-coupled receptor (GPCR) enriched in the hypothalamus and the brain stem, where it has been shown to regulate energy homeostasis, including feeding and glucose metabolism.
Gene structure and expression of serotonin receptor HTR2C in ...
2012年4月2日 · Although HTR2C has been implicated in genetic studies of human behavioural abnormalities, many of these have focussed on using well described polymorphic markers, either singly or as haplotypes. Results are contradictory, and currently the role of this specific receptor remains inconclusive.