2022年2月25日 · In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these …

2023年6月15日 · Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological processes depending on its …

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that …

2024年12月25日 · HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include Brachyphalangy, Polydactyly, And Tibial Aplasia/Hypoplasia …

High-mobility group box 1 (HMGB1) was initially recognized as a ubiquitous nuclear protein involved in maintaining the nucleosome integrity and facilitating gene transcription. HMGB1 …

High mobility group box 1 (HMGB1) was first isolated and characterized in calf thymus in 1973 and is named for its electrophoretic mobility on polyacrylamide gels. HMGB1 contains two …

HMGB1 is 215 amino acids long and consists of two DNA binding boxes (A box and B box) as well as a C-terminal tail that is highly enriched in anionic residues. Reflecting this structure, …

In this minireview, we introduce the basic structure and function of HMGB1 and focus on the regulatory mechanism of HMGB1 secretion and release. Understanding these topics may help …

2005年4月1日 · HMGB1 is a 'leaderless' cytokine, requiring specialized means to gain access to the immunological synapse or to be secreted. By contrast, after DNA damage as a result of …

2020年7月13日 · High mobility group box 1 (HMGB1) is a nonhistone chromatin-associated protein that has been widely reported to play a pivotal role in the pathogenesis of …