组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitor，HDACI），简称HDACIs，是一类化合物，有干扰与组蛋白去乙酰化酶的功能。 组蛋白去乙酰化酶抑制剂通常可分为两大类：NAD + -依赖性酶和Zn2 +依赖性酶。

Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally silenced heterochromatin, HDIs can render chromatin more transcriptionally active …

组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitor，HDACI）是一种干扰组蛋白去乙酰化酶的化合物，获批用于治疗多种血液癌症，特别是复发或难治的外周T细胞淋巴瘤（PTCL）。

Initially regarded as “epigenetic modifiers” acting predominantly through chromatin remodeling via histone acetylation, HDACIs, alternatively referred to as lysine deacetylase or simply deacetylase inhibitors, have since been recognized to exert multiple cytotoxic actions in cancer cells, often through acetylation of non-histone proteins.

组蛋白去乙酰化酶 (histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。 一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体结构松弛，从而使各种转录因子和协同转录因子能与DNA结合位点特异性结合，激活基因的转录。 而组蛋白的去乙酰化则发挥相反的作用。 组蛋白去 乙酰化酶 (histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和 基因表达调控 发挥着重要的作用。 一般情况下,组蛋白的乙酰化有利 …

Aug 13, 2007 · This review focuses on the mechanisms of action of histone deacetylase (HDAC) inhibitors (HDACi), a group of recently discovered ‘targeted’ anticancer agents.

Mar 29, 2018 · Histone deacetylases (HDACs) are key regulators of gene expression that act as transcriptional repressors by removing acetyl groups from histones. HDACs are dysregulated in many cancers, making them a therapeutic target for the treatment of cancer.

FDA已经批准了多种组蛋白去乙酰化酶抑制剂 (HDACi) 在临床上的使用，已有研究表明HDACi导致个别基因的promoter区域乙酰化水平降低，下调相关基因表达。此外，特别是对于癌细胞中高表达的基因而言，HDACi增加了染色体的开放性，并影响了enhancer的状态和染色质构 ...

组蛋白去乙酰化酶抑制剂（Histone Deacetylase Inhibitors, HDACi）是一类能够抑制组蛋白去乙酰化酶（HDAC）活性的化合物。 通过抑制HDAC活性，这些抑制剂能够增加组蛋白

Jan 1, 2023 · Histone deacetylase inhibitors (HDACi) are novel class of small natural or synthetic molecules that modify HDACs. These molecules function by inducing the hyperacetylation in histone and non-histone proteins, leading to a wide range of effects in both tumor and non-tumor cells. Numerous organic and synthetic substances serve as HDACi.