Histone deacetylase 5 - Wikipedia
Histone deacetylase 5 is an enzyme that in humans is encoded by the HDAC5 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and …
HDAC5 Gene - GeneCards | HDAC5 Protein | HDAC5 Antibody
Dec 25, 2024 · HDAC5 (Histone Deacetylase 5) is a Protein Coding gene. Diseases associated with HDAC5 include Anhidrosis, Isolated, With Normal Sweat Glands and Breast Cancer. …
一文带你了解组蛋白去乙酰化酶（HDAC） - 知乎专栏
HDAC8和HDAC11则优先水解非乙酰酰基赖氨酸底物，HDAC10则是一种多胺去乙酰化酶。 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转与羰基氧形 …
Insights Into the Function and Clinical Application of HDAC5 in …
HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we …
HDAC5, a Key Component in Temporal Regulation of p53 …
Nov 7, 2013 · K120 acetylation is a modification critical for recruitment of p53 to proapoptotic targets. Our data reveal that histone deacetylase 5 (HDAC5) binds to p53 and abrogates K120 …
本文将对HDAC5的结构表征和其在乳腺癌发生发展中的作用,以及HDAC5 抑制剂的应用作一简要总结,并 为早期乳腺癌HDACs的检测、HDACs 抑制剂(HDACi)的设计以及与HDACi 联用的相关 …
组蛋白去乙酰化酶 - 百度百科
组蛋白去乙酰化酶 (histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。 一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体 …
组蛋白去乙酰化酶（HDACs）小百科，一网打尽！ - 每日生物评论
在人单核细胞向巨噬细胞分化期间，HDAC5被上调。 另外，通过与转录因子PU.1相互作用并阻断靶基因的表达，HDAC3负调节骨髓细胞分化。 HDAC还通过控制炎症介质产生（例如细胞因 …
HDAC5 modulates SATB1 transcriptional activity to promote lung …
Jul 3, 2023 · Here we report that HDAC5 binds to and deacetylates SATB1 at the conserved lysine 411 residue. Furthermore, dynamic regulation of acetylation at this site is determined by …
10014 - Gene ResultHDAC5 histone deacetylase 5 [ (human)]
Jan 4, 2025 · HDAC5, negatively regulated by miR-148a-3p, promotes colon cancer cell migration. HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in …