组蛋白去乙酰化酶11 (histone deacetylases 11, HDAC11) 是IV 类HDAC 的唯一成员，能够催化组蛋白和非 组蛋白赖氨酸残基去乙酰化并具有去脂酰化活性。 HDAC11 与免疫细胞的成熟、分 …
HDAC11 Gene - GeneCards | HDA11 Protein | HDA11 Antibody
Dec 25, 2024 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell Lymphoma. …
HDAC11 - Wikipedia
Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5] [6] It is the only …
HDAC11: a multifaceted histone deacetylase with proficient …
The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of class IV. …
一文带你了解组蛋白去乙酰化酶（HDAC） - 知乎专栏
hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转 …
聚焦药靶：HDAC抑制剂的最新研究进展 - 健康界
Sep 6, 2021 · 唯一的Ⅳ类hdac是hdac11，其与Ⅰ类和Ⅱ类酶的催化核心区域具有序列同源性，但是不具有足够的相似性。 图片来源：ResearchGate HDAC抑制剂是潜在的抑制增殖的化合 …
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase …
Mar 12, 2022 · This study provided evidence that HDAC11 is highly expressed in the aortic intima of HFD-fed ApoE −/− mice and HDAC11 knockdown significantly suppressed pyroptosis via …
The histone deacetylase HDAC11 regulates the expression of …
Nov 16, 2008 · Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively regulated expression of the gene …
HDAC11: A novel target for improved cancer therapy - PubMed
Sep 3, 2023 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In …
组蛋白去乙酰化酶 - 百度百科
组蛋白去乙酰化酶(histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体 …