
Histone H4 lysine 20 methylation: key player in epigenetic
2013年3月1日 · Intense research during the past few years has revealed histone H4 lysine 20 methylation (H4K20me) as critically important for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction.
Histone H4 lysine 20 mono-methylation directly facilitates ... - Nature
2021年8月20日 · Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin...
H4K20me0 recognition by BRCA1–BARD1 directs homologous ... - Nature
2019年2月25日 · We show that BRCA1 recruitment requires recognition of histone H4 unmethylated at lysine 20 (H4K20me0), linking DSB repair pathway choice directly to sister chromatid availability.
Structural basis of nucleosomal H4K20 recognition and ... - Nature
2023年12月5日 · Histone lysine methyltransferase SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 lysine 20 (H4K20), has crucial roles in DNA-templated processes, including DNA...
Catalytic and non-catalytic mechanisms of histone H4 lysine 20 ...
2023年8月17日 · Abini-Agbomson et al. uncover the mechanisms of SUV420H1, a histone H4K20 methyltransferase involved in DNA replication, DNA repair, and heterochromatin formation. They determine several SUV420H1-nucleosome structures to understand its catalytic activity and stimulation by histone variant H2A.Z.
Histone H4 Lysine 20 (H4K20) Methylation, Expanding the …
We review the signaling pathways and functions associated with a single residue, H4K20, as a model chromatin and clinically important mark that regulates biological processes ranging from the DNA damage response and DNA replication to gene expression and silencing. The human genome consists of greater than 20,000 protein-coding genes (1).
Structural insight into H4K20 methylation on H2A.Z-nucleosome …
Histone variant H2A.Z is crucial for early replication origins licensing and activation in which SUV420H1 preferentially recognizes H2A.Z-nucleosome and deposits H4 lysine 20 dimethylation (H4K20me2) on replication origins.
H4K20me3: Key Insights on Chromatin and Gene Regulation
3 天之前 · Dimethylation of H4K20 is associated with DNA damage response and chromatin compaction. Unlike H4K20me1, which is linked to transcriptional activity, H4K20me2 is more abundant in heterochromatin and serves as a platform for DNA repair protein recruitment. It is catalyzed by SUV4-20H1 and SUV4-20H2, which convert H4K20me1 to its dimethylated state.
H4K20 methylation regulates quiescence and chromatin compaction
2013年10月1日 · H4K20 is differentially methylated in quiescent fibroblasts. Given our observation that contact-inhibited fibroblasts pack chromatin more tightly than proliferating or restimulated fibroblasts, we sought to uncover histone modification changes that are associated with quiescence in this system.
Histone H4K20 Review - EpiGenie
This recent review is devoted to examining the roles of all H4K20 methylations. The review goes through many biological processes and lists details of how the three methylation states are involved in each.
- 某些结果已被删除