2013年3月1日 · Intense research during the past few years has revealed histone H4 lysine 20 methylation (H4K20me) as critically important for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction.

2021年8月20日 · Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin...

2019年2月25日 · We show that BRCA1 recruitment requires recognition of histone H4 unmethylated at lysine 20 (H4K20me0), linking DSB repair pathway choice directly to sister chromatid availability.

2023年12月5日 · Histone lysine methyltransferase SUV420H1, which is responsible for site-specific di-/tri-methylation of histone H4 lysine 20 (H4K20), has crucial roles in DNA-templated processes, including DNA...

2023年8月17日 · Abini-Agbomson et al. uncover the mechanisms of SUV420H1, a histone H4K20 methyltransferase involved in DNA replication, DNA repair, and heterochromatin formation. They determine several SUV420H1-nucleosome structures to understand its catalytic activity and stimulation by histone variant H2A.Z.

We review the signaling pathways and functions associated with a single residue, H4K20, as a model chromatin and clinically important mark that regulates biological processes ranging from the DNA damage response and DNA replication to gene expression and silencing. The human genome consists of greater than 20,000 protein-coding genes (1).

Histone variant H2A.Z is crucial for early replication origins licensing and activation in which SUV420H1 preferentially recognizes H2A.Z-nucleosome and deposits H4 lysine 20 dimethylation (H4K20me2) on replication origins.

3 天之前 · Dimethylation of H4K20 is associated with DNA damage response and chromatin compaction. Unlike H4K20me1, which is linked to transcriptional activity, H4K20me2 is more abundant in heterochromatin and serves as a platform for DNA repair protein recruitment. It is catalyzed by SUV4-20H1 and SUV4-20H2, which convert H4K20me1 to its dimethylated state.

2013年10月1日 · H4K20 is differentially methylated in quiescent fibroblasts. Given our observation that contact-inhibited fibroblasts pack chromatin more tightly than proliferating or restimulated fibroblasts, we sought to uncover histone modification changes that are associated with quiescence in this system.

This recent review is devoted to examining the roles of all H4K20 methylations. The review goes through many biological processes and lists details of how the three methylation states are involved in each.