综合上述发现，研究认为 组蛋白H3K36M 突变造成的H3K36me2修饰水平降低导致了细胞分化相关基因的异常表达，是其促癌机制中的关键因素。 同时，还有一些重要的问题需要更多工作来 …

本研究揭示DNMT3A优先选择H3K36二甲基化区域，促进基因间区的DNA甲基化，并且Sotos综合征病人的血样和NSD1突变肿瘤中都出现了基因间区DNA甲基化的选择性丢失。 这一工作 …

Jan 8, 2025 · We find that H3K36 methylation reinforces expression of cell-type-associated genes to maintain specialized cell identity in intestinal epithelial cells. Depleting H3K36 methylation …

Ko et al. show that disrupting the epigenome via the expression of a mutant histone (H3K36M) promotes chromatin alterations that drive a striking increase in epithelial gland formation …

H3G34W and H3K36M IHC is highly specific for GCT and chondroblastoma, respectively, among giant cell-rich bone tumors, and is useful for confirming the diagnosis in limited biopsies. The …

May 13, 2016 · Here we report that the H3 lysine 36–to–methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in …

Jul 17, 2023 · At a molecular level, H3K36M enables the decommissioning of mesenchymal enhancers and the parallel activation of epithelial/stem cell enhancers. This enhancer rewiring …

Feb 13, 2024 · Approximately 20% of head and neck squamous cell carcinomas (HNSCCs) exhibit reduced methylation on lysine 36 of histone H3 (H3K36me) due to mutations in histone …

h3k36m 是软骨母细胞瘤中的潜在致癌驱动突变；还见于儿童软组织肉瘤和 hnscc。 它可以抑制 SETD2 与 NSD 家族的甲基转移酶，从而阻止组蛋白甲基化。 推荐 Ab ID： ab256384 。

Mar 2, 2021 · Hotspot histone H3 mutations have emerged as drivers of oncogenesis in cancers of multiple lineages. Specifically, H3 lysine 36 to methionine (H3K36M) mutations are …