H3K9me3 - Wikipedia
H3K9me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation at the 9th lysine residue of the histone H3 protein and is often associated with heterochromatin.
The Emerging Role of H3K9me3 as a Potential Therapeutic Target …
Histone 3 lysine 9 trimethylation (H3K9me3) is a post-translational modification known to be involved in the regulation of a broad range of biological processes, including the formation of transcriptionally silent heterochromatin.
Establishment of H3K9-methylated heterochromatin and its
May 13, 2021 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it...
Distinct H3K9me3 heterochromatin maintenance dynamics …
Oct 31, 2024 · H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes and DNA repeats. Our...
The control of gene expression and cell identity by H3K9 …
Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements.
TNRC18 engages H3K9me3 to mediate silencing of endogenous …
Nov 8, 2023 · Collectively, we describe a new H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young ERVs and exert substantial effects on host genome integrity,...
Role of H3K9me3 heterochromatin in cell identity establishment …
The ability of H3K9me3 to influence cell identity challenges the original concept of H3K9me3-marked heterochromatin as mainly a constitutive type of chromatin and provides a further level of understanding of how to modulate cell fate control.
H3K9 methylation regulates heterochromatin silencing through
Jun 26, 2024 · Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription silencing and how cells delimit H3K9me domains to avoid silencing essential genes.
Frontiers | The Emerging Role of H3K9me3 as a Potential …
Aug 1, 2019 · Histone 3 lysine 9 trimethylation (H3K9me3) is a post-translational modification known to be involved in the regulation of a broad range of biological processes, including the formation of transcriptionally silent heterochromatin.
The silent guardian: unraveling the roles of H3K9me3 in genome ...
Jul 2, 2024 · In this review, we provide a comprehensive summary of the multifaceted roles of H3K9me3, a histone mark associated with silent chromatin, in DNA damage repair and genome maintenance, elucidating its dynamic participation in chromatin organization, silencing of repetitive DNA sequences, and modulation of DNA repair pathways.