2021年5月13日 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite repeats and genes, where it...

2021年5月13日 · Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and overlaps well with...

2021年11月4日 · Gasser and colleagues report that H3K9me2 and H3K9me3 repress lineage-specific and germline genes by restricting the activity of a subset of transcription factors in terminally differentiated...

Here we show that histone 3 lysine 9 dimethylation (H3K9me2) is an evolutionarily conserved, specific mark of nuclear peripheral heterochromatin and that it is retained through mitosis. During mitosis, phosphorylation of histone 3 serine 10 temporarily shields the H3K9me2 mark allowing for dissociation of chromatin from the nuclear lamina.

2022年9月20日 · Non-CG methylation and H3K9me2 reinforce each other through a feedback loop: methylated CHG and CHH recruit the H3K9-specific methyltransferases SUVH4, SUVH5, and SUVH6, and in turn, H3K9me2 facilitates CMT3 and CMT2 function to methylate DNA in the CHG and/or CHH context [8, 18,19,20].

2020年5月6日 · In this review, we summarize work from the recent studies regarding the regulation of H3K9me2, emphasizing the process of deposition and reading and the biological significance of H3K9me2 in Arabidopsis.

2019年10月1日 · The H3K9me2 modification of peripheral heterochromatin ensures that positional information is safeguarded through cell division such that individual LADs are re-established at the nuclear periphery in daughter nuclei. Thus, H3K9me2 acts as a 3D architectural mitotic guidepost.

2024年6月26日 · Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and transcriptionally silent heterochromatin. It remains unclear how H3K9me controls transcription silencing and how cells delimit H3K9me domains to avoid silencing essential genes.

2020年8月1日 · Here, we investigated the functional roles of H3 lysine 9 dimethylation (H3K9me2), one of the abundant histone modifications, in three-dimensional (3D) genome organization.

2020年4月8日 · In 2017, a study in S. pombe revealed that H3K9me2 and H3K9me3 have distinct roles in gene silencing, with H3K9me2 being permissive for transcription 22. Our work identifies Abo1 as a new factor involved in the H3K9 methylation process.