GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to …

S-Nitrosoglutathione (GSNO) is an endogenous S -nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO. NO coexists in cells with SNOs that serve as endogenous NO carriers and donors.

炎症因子的表达调控是炎症反应的关键步骤，与自身免疫疾病以及癌症等密切相关．一氧化氮 (nitric oxide，NO)在炎症因子表达调控中具有重要作用，但已有的研究多关注于NO合成对炎症因子的调控作用，而对NO代谢的作用知之甚少．亚硝基化谷胱甘 肽还原酶 (S ...

该研究发现了心肌肥厚中调控MLP巯基亚硝基化修饰的酶是谷胱甘肽还原酶(S-nitrosoglutathione reductase, GSNOR)。 GSNOR是一种去巯基亚硝基化修饰蛋白，在心肌肥厚时，其表达降低促进靶蛋白巯基亚硝基化修饰水平增加，促进心肌肥厚。

We are studying the enzyme S-nitrosoglutathione reductase (GSNOR), originally identified in plants and other organisms as formaldehyde dehydrogenase (FALDH), a type III alcohol dehydrogenase. Using mutants of GSNOR in Arabidopsis (hot5 mutants), we have shown that GSNOR is ciritical to nitric oxide homeostasis.

Jul 5, 2023 · 该论文首次发现GSNOR在心肌细胞线粒体定位，并明确线粒体GSNOR（谷胱甘肽还原酶，S-nitrosoglutathione reductase）通过调控线粒体蛋白ANT1（腺嘌呤核苷酸转位酶1，ADP/ATP translocase 1）的巯基亚硝基化修饰影响线粒体功能，参与心肌重构和心衰进程。

Feb 1, 2021 · In this review, we focus on the emerging role of GSNOR as a master regulator in oxidative stress through its regulation of the interaction of ROS, RNS, and Fe, and highlight recent discoveries in post-translational modifications of GSNOR and functional variations of natural GSNOR variants during oxidative stress.

GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to …

Apr 3, 2024 · Our findings suggested that GSNOR is a regulator of the NLRP3 inflammasome and that reducing the level of S -nitrosylated MAPK14 may constitute an effective strategy for alleviating diseases...

Aug 11, 2022 · S-亚硝基谷胱甘肽还原酶（GSNOR）由ADH5基因编码，是乙醇脱氢酶（ADH）家族中的成员。前人研究发现，生物体内的GSNOR能调控多种蛋白的S-亚硝基化，参与多种生理和病理过程。CDK5是周期蛋白依赖激酶家族中的成员。该课题组前期已经发现，MPTP能诱导CDK5介导的自 ...