GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell …

2024年12月25日 · GPNMB (Glycoprotein Nmb) is a Protein Coding gene. Diseases associated with GPNMB include Amyloidosis, Primary Localized Cutaneous, 3 and Lichen Amyloidosis. …

GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are …

2022年9月1日 · This review provides a description of the emerging roles of GPNMB as an inducer of immunosuppression, with a particular focus on its role in mediating cancer progression by …

Glycoprotein-NMB (GPNMB) is a transmembrane glycoprotein that is overexpressed in a variety of cancers. It can promote primary tumor growth and metastasis, and GPNMB expression …

The glycoprotein nonmetastatic melanoma protein B (GPNMB, also known as osteoactivin) is highly expressed in many cell types and regulates the homeostasis in various tissues. In …

2025年2月8日 · GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may …

GPNMB is a type I transmembrane protein that contains an N-terminal signal peptide, an integrin-binding (RGD) motif and a polycystic kidney disease (PKD) domain in its extracellular domain …

2025年3月4日 · GPNMB overexpression is closely related to a weak immune state in L-Lep. As a key part of innate immunity and a major host of leprosy pathogens, macrophage dysfunction is …

单细胞+转录组测序：高表达GPNMB的巨噬细胞促进了GBM中的PN-MES转变并阻碍了 T细胞 的激活. 本研究通过 单细胞RNA测序 （scRNA-seq）、 bulk RNA-seq 和 空间转录组测序 技术 …