
NMDA receptor - Wikipedia
The basic structure and functions associated with the NMDA receptor can be attributed to the GluN2B subunit. For example, the glutamate binding site and the control of the Mg 2+ block …
GluN2A and GluN2B NMDA receptors use distinct allosteric routes - Nature
2021年8月5日 · Here the authors show that GluN2A and GluN2B NMDA receptors — the two principal subtypes NMDARs in the adult CNS — operate through distinct long range allosteric …
The differences between GluN2A and GluN2B signaling in the …
GluN2A and GluN2B are the main types of NMDA receptor subunit in the adult forebrain. Studies have demonstrated that they play different roles in a number of pathophysiological processes.
Recent progress in the development of GluN2B selective ligands
2023年6月2日 · Understanding of design rules and roles of GluN2B selective compounds will provide the link to medicinal chemists and neuroscientists to explore novel neurotherapeutic …
GluN2A and GluN2B subunit-containing NMDA receptors in …
Unfortunately, the results from studies that have investigated this hypothesis are contradictory, particularly in relation to LTD. Nevertheless, current evidence does suggest that the GluN2B …
GluN2A and GluN2B NMDA receptors use distinct allosteric routes
Here, combining functional and structural interrogation, we reveal that GluN2A and GluN2B receptors utilize different long-distance allosteric mechanisms involving distinct subunit-subunit …
GluN2A versus GluN2B: twins, but quite different - PMC
In this review, we focus on GluN2A and GluN2B, the primary NMDAR subunits in the cortex and hippocampus, and discuss their differences in developmental expression, brain distribution, …
GluN2B-mediated regulation of silent synapses for receptor ...
GluN2B ablation reduces the proportion of silent synapses, but some of them can persist by substitution with GluN2C, which drives the aberrantly facilitated synaptic incorporation of …
A common mechanism allows selective targeting of GluN2B …
2019年11月15日 · Overactivation leads to high intracellular Ca 2+ concentrations and cell death rendering GluN2B-selective inhibitors as promising drug candidates. Ifenprodil represents the …
Ubiquitination and functional modification of GluN2B subunit …
2020年6月30日 · In this study, we found a specific interaction of Cbl-b with GluN2B subunit and demonstrated that Cbl-b binding to GluN2B was involved in the modification of NMDAR …