Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called …

2020年7月24日 · To date, diverse and largely host-cell-derived molecules have been identified as cognate antigens for the γδ TCR. However, for most γδ TCRs, the activating ligand is still …

On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large compartments of γδTCR + intraepithelial lymphocytes (γδ IELs) exhibit …

2024年4月24日 · Gamma delta (γδ) T cells, a unique T cell subgroup, are crucial in various immune responses and immunopathology 1, 2, 3. The γδ T cell receptor (TCR), which is …

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2018年11月12日 · Hence, the γδTCR intrinsically combines innate immunity and adaptive immunity by using spatially distinct regions to discriminate non-clonal agonist-selecting …

Here, we reveal a regulatory axis where T cell receptor (TCR) signaling controls TCF1 expression through an E-protein-bound regulatory element in the locus, and this. axis regulates both gd T …

2002年5月1日 · γδ T cell receptors (γδ TCRs), αβ T cell receptors (αβ TCRs) and antibodies are all products of gene rearrangement that provide the vertebrate immune system with the ability …

2019年3月28日 · In this review, we will discuss the current state of knowledge of the molecular mechanism of TCR signal transduction and its role in the thymic development of γδT cells, …

2019年10月8日 · In contrast to the previous assumption of the general allo-HLA reactivity of a minor fraction of γδTCRs, we show that classic anti-HLA–directed, γδTCR-mediated reactivity …