2024年12月25日 · GDF10 (Growth Differentiation Factor 10) is a Protein Coding gene. Diseases associated with GDF10 include Prostate Cancer and Endometrial Clear Cell Adenocarcinoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene. [5] GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein -3 (BMP3).

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。 编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。 这促进了中风后的神经修复。 此外，这种蛋白质可能充当肿瘤抑制因子，并且这种基因的表达减少与口腔癌有关。 [RefSeq 提供，2016 年 7 月] This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily …

骨形态发生蛋白 3 (bmp-3; gdf10) 是一种多效性配体蛋白，属于 tgfβ 家族。 BMP-3 是成骨素的主要成分，具有成骨活性。 BMP-3 在致癌过程中发挥抑制作用，通过 ActRIIB/ SMAD2 依赖性和 TAK1/ JNK 信号通路抑制结肠肿瘤的发生。

GDF10 inhibits cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma by the transforming growth factor-beta/Smad and NF-kappaB pathways.

GDF10（Growth Differentiation Factor 10）是一种TGF-β超家族的蛋白，也被称为BMP3B（Bone Morphogenetic Protein 3B）。 它是一种密切相关的生长因子，对于细胞增殖、分化和细胞起着重要作用。

2022年3月24日 · GDF10 was downregulated in NPC owing to its aberrant promoter methylation. After treatment with 5-aza-2'-deoxycytidine, the expression of GDF10 in NPC cells was reversed. We also confirmed that the overexpression of GDF10 significantly inhibited cell proliferation and tumor growth both in vitro and in vivo, respectively.

2024年11月1日 · We now show a significant induction of circulating levels of growth differentiation factor 10 (GDF10) in TDAG51 −/− mice, which was of interest due to its established role as an inhibitor of osteoblast differentiation. The objective of this study was to examine the role of GDF10 in the osteogenic transdifferentiation of VSMCs.

2015年10月26日 · GDF10 promotes axonal outgrowth in vitro in mouse, rat and human neurons through TGFβRI and TGFβRII signaling. Using pharmacogenetic gain- and loss-of-function studies, we found that GDF10...

2019年5月31日 · We found that growth differentiation factor-10 (GDF10), a member of the TGF-β superfamily, was downregulated in tumor samples. Further analysis of GDF10 expression in a larger set of clinical TNBC samples using qPCR confirmed its downregulation and association with parameters of disease severity.