Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family .

The cause of this anti-aging phenomenon remained a mystery until May 2013, when Wagers, PhD, and cardiologist Richard Lee, MD, found that a protein in the blood of young mice, called GDF11, was able to quickly reverse symptoms of heart failure in older mice.

Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength.

Nov 17, 2023 · In vitro GDF11 deletion causes cellular senescence in Neuro-2a cells. Mechanistically, GDF11 deletion induces neuronal senescence via Smad2-induced transcription of the pro-senescence factor...

Dec 25, 2024 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and Orofacial Clefting Syndrome. Among its related pathways is …

Feb 8, 2025 · GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression. Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension.

Bone Morphogenetic Protein 11 (BMP 11) or Growth/Differentiation Factor 11 (GDF 11) is a BMP/Transforming Growth Factor β (TGF β) family member protein that is globally secreted in several species including humans, mice, rats, etc.

Growth differentiation factor (GDF11) is a member of TGF-β/BMP superfamily that activates Smad and non-Smad signaling pathways and regulates expression of its target nuclear genes.

Jun 1, 2023 · GDF11 (Growth differentiation factor 11) is a newly discovered member of family of transforming growth factors-β. Its crucial role was confirmed in physiology, i.e. embryogenesis due to its involvement in bone formation, skeletogenesis and it …

Apr 1, 2016 · GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues, whereas myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes.

Jun 1, 2023 · Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β superfamily that has garnered significant attention due to its anti-cardiac aging properties. Many studies have revealed that GDF11 plays an indispensable role in the onset of cardiovascular diseases (CVDs).

GDF11 is expressed in many tissues, including skeletal muscle, pancreas, kidney, nervous system, and retina, among others. GDF11 circulating levels and protein content in tissues are quite variable and are affected by pathological conditions or age.

GDF11 is a secreted factor in the TGFß family of cytokines. Its nearest neighbor evolutionarily is myostatin, a factor discovered as being a negative regulator of skeletal muscle growth.

Feb 2, 2023 · Here, we demonstrate that systemic administration of growth differentiation factor 11 (GDF11) in aged mice improves memory and alleviates senescence and depression-like symptoms in a...

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP11), has been identified as a key player in various biological processes, including embryonic development, aging, metabolic disorders and cancers.

Jun 1, 2023 · Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β superfamily that has garnered significant attention due to its anti-cardiac aging properties. Many studies have revealed that GDF11 plays an indispensable role in the onset of cardiovascular diseases (CVDs).

Dec 8, 2020 · Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β superfamily of cytokines, is a critical rejuvenation factor in aging cells. GDF11 improves neurodegenerative and neurovascular disease outcomes, increases skeletal muscle volume, and enhances muscle strength.

The cardiovascular role of growth differentiation factor (GDF)-11, a member of the transforming growth factor (TGF)-β superfamily, is controversial. In 2013, we reported that heterochronic parabiosis, whereby 2 mice of different ages (“heterochronic”) are joined together to share a common circulation, reduced cardiac hypertrophy in the old ...