GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

Dec 25, 2024 · GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

Gene expression profiling has shown that GATA-3 is highly expressed in the Luminal A subtype of breast cancer. A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status.

GATA-3 is particularly important in the development of T cells and is a key regulator in the immune system, influencing the development of the Th2 (T helper 2) cell lineage, which is …

GATA3 is a useful marker in the characterization of not only mammary and urothelial but also renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker to detect metastatic mammary or urothelial carcinomas.

GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence “GATA”, which enables its key role in ...

GATA3 has conventionally been regarded as a transcription factor that drives the differentiation of T helper (Th) 2 cells. Increasing evidence points to function for GATA3 beyond controlling Th2 differentiation. GATA3 regulates T cell development, proliferation and maintenance.

In immune cells, GATA3 is best known to function as a master regulator of T helper 2 (T H 2)-cell differentiation. However, in recent years GATA3 has been found to have additional crucial...

Studies have shown that GATA3 immunostaining could be a useful tool in various tumors in kidney, salivary gland, endocrine system, hematopoietic system, and skin. GATA3 can also be used as a useful prognostic tool.

GATA3 is the main GATA-family member that is expressed by immune cells, and can be easily detected in developing and mature T cells, natural killer (NK) cells and CD1-restricted NKT cells 3-5. Indeed, several recent studies have revealed …