Dec 25, 2024 · GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Deafness, Autosomal Recessive 26 and Glioblastoma. Among its related pathways are Downstream signaling of activated …

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. [5] The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family.

Gab1 is a multiadaptor protein that has been shown to be required for multiple processes in embryonic development and oncogenic transformation. Gab1 functions by amplifying signal transduction downstream of various receptor tyrosine kinases through ...

We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1-induced mitogen-activated protein kinase (MAPK) stimulation is not affected by Gab1 deficiency.

Mar 11, 2003 · Grb2-associated binder-1 (Gab1) is a pleckstrin homology (PH) domain-containing adapter molecule that is believed to function downstream of receptors for growth factors and cytokines.

Feb 8, 2025 · Gab1 is a unique negative regulator of the thymus-independent antigen-2 response specifically expressed in splenic marginal zone B cells. coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells

Aug 20, 2023 · GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, GAB1 transitions from the cytoplasm to the membrane where it …

Oct 24, 2019 · Grb2-associated binder (Gab) family proteins are multi-site docking proteins, which expand cytokine-induced signal transduction in a spatial- and time-dependent manner by coordinating the recruitment of proteins involved in mitogen activated protein kinase (MAPK)/extracellular-signal regulated kinase (ERK) and phosphatidyl-inositol-3-kinase (PI3...

Oct 9, 2016 · Title: Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis. Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children.

Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional analysis of Gab1 by targeted mutagenesis in the mouse, and compare the phenotypes of the Gab1 and c-Met mutations.