In this review, we first describe the structure and function of GPX4, then outline the novel roles of GPX4 in cell death and autophagy, and finally discuss the impact of GPX4 on embryonic development and disease.

Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the …

2024年12月25日 · GPX4 (Glutathione Peroxidase 4) is a Protein Coding gene. Diseases associated with GPX4 include Spondylometaphyseal Dysplasia, Sedaghatian Type and Bone Disease. Among its related pathways are Biosynthesis of specialized proresolving mediators (SPMs) and Fatty acid metabolism.

2023年5月1日 · Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the cell aging, oncogenesis, and cell death.

2022年10月30日 · Glutathione peroxidase 4 (GPX4) acts as a master regulator in the ferroptosis process, and its unique function is to interrupt lipid peroxidation by converting lipid hydroperoxides into...

2024年5月1日 · GPX4 as a key target to counteract ferroptosis is closely related to diseases. GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body.

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) ...

GPX4 is a key ferroptosis biomarker and correlated with immune cell populations and immune checkpoints in childhood sepsis. IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis.

Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products.

2025年2月25日 · We conclude that GPX4 and PC expression are inversely related in TNBC cells, and GPX4 and obesity interact to impact TNBC progression and treatment responses. Moreover, GPX4-mediated redox defense, alone or in combination with chemotherapy, is a targetable vulnerability for treating TNBC, including obesity-related TNBC.