G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119 gene. [5] GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors. [6] [7] [8]

2022年11月17日 · Agonists selectively targeting cannabinoid receptor-like G-protein-coupled receptor (GPCR) GPR119 hold promise for treating metabolic disorders while avoiding unwanted side effects.

2024年12月25日 · GPR119 (G Protein-Coupled Receptor 119) is a Protein Coding gene. Diseases associated with GPR119 include Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1 and Lynch Syndrome 2. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts.

GPR119 has been a potential therapeutic target for diabetes mellitus type 2 for many years, but its role in metabolic dysfunction associated fatty liver disease deserves further attention.

GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas (β-cells) and gastrointestinal tract (enteroendocrine cells) in humans. De-orphanization of GPR119 has revealed two classes of possible endogenous ligands, viz., phospholipids and fatty acid amides.

2021年8月1日 · GPR119 monitors physiological mechanisms that enhance homeostasis of glucose, such as glucose-like peptide-1, gastrointestinal incretin hormone levels, pancreatic beta cell-dependent insulin secretion and glucose-dependent insulinotropic peptide (GIP).

GPR119 monitors physiological mechanisms that enhance homeostasis of glucose, such as glucose-like peptide-1, gastrointestinal incretin hormone levels, pancreatic beta cell-dependent insulin secretion and glucose-dependent insulinotropic peptide (GIP).

GPR119 is a G protein-coupled receptor expressed on intestinal L cells that synthesize and secrete the blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1). GPR119 agonists stimulate the release of GLP-1 from L cells, and for this reason ...

GPR119 is a G protein-coupled receptor expressed predominantly in the pancreas (beta-cells) and gastrointestinal tract (enteroendocrine cells) in humans. De-orphanization of GPR119 has revealed two classes of possible endogenous ligands, viz., phospholipids and fatty acid amides.

2014年7月30日 · GPR119. GPR119 is expressed predominantly in the brain, gastrointestinal tract, and pancreas where it has been shown to regulate the secretion of insulin making it an attractive target for the treatment of diabetes.