Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] GDF11 is a member of the Transforming growth factor beta family .

The cause of this anti-aging phenomenon remained a mystery until May 2013, when Wagers, PhD, and cardiologist Richard Lee, MD, found that a protein in the blood of young mice, called GDF11, was able to quickly reverse symptoms of heart failure in older mice.

Dec 25, 2024 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and Orofacial Clefting Syndrome. Among its related pathways is …

Oct 14, 2019 · GDF11 (also known as Bone Morphogenetic Protein, BMP11), is a member of the super family of the Transforming Growth Factor beta (TGF-β) and a subfamily of the BMP which is widely secreted in many species, including mouse, rat and human, and it is accepted as a key factor in embryo development, particularly in the anterior/posterior patterning (7...

Sep 6, 2024 · Growth Differentiation Factor 11 (GDF11) is a circulating member of the transforming growth factor β (TGF-β) superfamily that has essential roles in mammalian development. Genetic knockout studies have revealed the far-reaching effects of GDF11 on the developing embryo.

Mar 3, 2017 · Here we show that, despite their high similarity, GDF11 is a more potent activator of SMAD2/3 and signals more effectively through the type I activin-like receptor kinase receptors ALK4/5/7 than GDF8.

May 7, 2014 · Researchers from the Harvard Stem Cell Institute (HSCI) have shown that injections of a protein dubbed GDF11, when administered to older mice, appear to cause a reversal of many signs of aging.

2 days ago · Growth differentiation factor 11 (GDF11), a member of the transforming growth factor β (TGF-β) superfamily, exhibits great neurological and mental diseases modulating potential. However, its specific effects on microglia, which are the primary immune cells of the nervous system, remain unclear. To investigate the mechanism by which GDF11 affects BV2 microglial …

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning …

生长分化因子11（growth differentiation factor-11，GDF11）是 转化生长因子β （transforming growth factor-β, TGF-β）超家族中 骨形态发生蛋白 （bone morphogenetic proteins, BMPs）亚家族中的一个重要成员，在哺乳动物的骨骼、肾等多种器官组织上均有表达，除了与哺乳动物的抗衰老作用联系越来越紧密，GDF11在胚胎发育、骨骼和肌肉形成等方面也起着重要作用。 最*的 …