2021年1月15日 · General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase (HAT) and lysine acetyltransferase (KAT).

2023年9月1日 · As the first histone acetyltransferase to be cloned and identified in yeast, general control non-depressible 5 (GCN5) plays a crucial role in epigenetic and chromatin modifications. It has been extensively studied for its essential role in regulating and causing various diseases.

Understanding the functions of GCN5/PCAF in developmental processes provides clues to the roles of these KATs in disease states. Here we will review what is currently known about the developmental roles of GCN5 and PCAF, as well as emerging role of these KATs in oncogenesis. Keywords: Gcn5, Pcaf, chromatin, development, cancer. 1. Introduction.

2021年2月1日 · Thus, the identification of Gcn5 as a nuclear histone acetyltransferase provided a clear connection between an enzyme that modified histones within chromatin and gene expression, supporting Allfrey's original hypothesis that histone acetylation could act as a switch to control RNA synthesis.

2023年6月23日 · As the first histone acetyltransferase to be cloned and identified in yeast, general control non-depressible 5 (GCN5) plays a crucial role in epigenetic and chromatin modifications. It has been extensively studied for its essential role in regulating and causing various diseases.

GCN5 has a major impact on energy metabolism by i) sensing acetyl-CoA, a central metabolite and substrate of the GCN5 catalytic reaction, and ii) acetylating proteins such as PGC-1α, a transcriptional coactivator that controls genes linked to …

In this review, we have discussed the structural features, the biological function of GCN5 and the mechanical link with the diseases associated with its imbalance. Moreover, the present GCN5...

GCN5 was defined biochemically as the first transcription-linked HAT [7] with specificity for histone H3 lysine 14 (H3K14) [8]. However, GCN5 could also acetylate additional histone lysine residues, such as H3K9, H3K18, H3K23, H3K27, H3K36, …

2021年1月14日 · In this review, we have discussed the structural features, the biological function of GCN5 and the mechanical link with the diseases associated with its imbalance. Moreover, the present GCN5...

2025年3月8日 · GCN5 is highly expressed in high-grade gliomas. To identify significant molecular markers for the malignant evolution of gliomas, we analyzed clinical information and transcript expression data ...