Sep 4, 2023 · Liquid Chromatography (LC) and Gas Chromatography (GC) are two distinct analytical techniques used for the separation and analysis of compounds in complex mixtures. Here are 15 key differences between LC and GC:

Aug 21, 2023 · Chromatography is classified into two types based on the physical state of the mobile phase used – liquid chromatography (LC) and gas chromatography (GC).

Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) are two powerful analytical techniques used in the field of analytical chemistry. Both methods are widely used for the identification and quantification of compounds in …

Mar 3, 2024 · Gas chromatography (GC) involves vaporizing samples and passing them through a column with a carrier gas, allowing separation based on volatility. Liquid chromatography (LC), on the other hand, separates compounds dissolved in a liquid phase, based on their interaction with the column's stationary phase.

Jul 30, 2017 · In order to identify and account for all substances in a particular difficult sample or mix, LC-MS or GC-MS can be used to ease and hasten the identification process. “LC-MS” is the abbreviated form of “liquid chromatography mass spectrometry.”

Mar 6, 2012 · Practical advice, tutorials, and peer-reviewed research on liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS) and related techniques.

Aug 23, 2024 · LC uses a liquid mobile phase, making it suitable for larger, non-volatile molecules, whereas GC employs a gaseous mobile phase, ideal for small, volatile compounds. Understanding their similarities and differences is crucial for selecting the appropriate method for specific analyses.

The GC part of a GC-MS, termed the chromatograph, generates a plot called a chromatogram. The chromatogram is a graph showing amount of molecules on the y axis and time on the x-axis. Retention time is the amount of time it takes a compound to move through the GC.

GC-MS is primarily used for volatile and semi-volatile compounds, as it requires the sample to be in the gas phase. On the other hand, LC-MS is suitable for a wider range of compounds, including non-volatile and polar substances, as it operates with liquid samples.

In liquid chromatography (LC), the flowing or mobile phase is a liquid, whereas in gas chromatography (GC) is a gas. Detection of the separated components in both GC and LC can be made by various means, one of the most sensitive being a mass spectrometer.