FOSL1 - Wikipedia
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. [5][6] The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes …
FRA-1: A key factor regulating signal transduction of tumor
Fos-related antigen-1 (FRA-1) is a member of activator protein-1 (AP-1) transcription factor superfamily, and FRA-1 is highly expressed in colon cancer, breast cancer, gastric cancer, …
Review FRA-1: A key factor regulating signal transduction of …
Jun 1, 2022 · FRA-1 plays a key role in regulating inflammatory reaction, and interleukin signal transduction related gene expression. FRA-1 can promote the proliferation or apoptosis of …
The nuclear oncoprotein Fra-1: a transcription factor knocking on ...
May 8, 2020 · Among the FOS -related members of the AP-1 dimeric complex, the transcription factor Fra-1, encoded by FOSL1, is crucially involved in human tumor progression and …
The Fra-1: Novel role in regulating extensive immune cell states …
Aug 10, 2022 · Fra-1 (Fos-related antigen1), a member of transcription factor activator protein (AP-1), plays an important role in cell proliferation, apoptosis, differentiation, inflammation, …
FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer
May 5, 2023 · Among FOS-related components of the dimeric AP-1 transcription factor, the oncoprotein FRA-1 (encoded by FOSL1 ) is a key regulator of invasion and metastasis. The …
The Fra-1/AP-1 Oncoprotein: From the "Undruggable ... - PubMed
Mar 14, 2022 · Among components of the AP-1 complex, the FOS-family transcription factor Fra-1, encoded by FOSL1, has emerged as a prominent therapeutic target. Fra-1 is overexpressed …
FRA-1：调节肿瘤细胞信号转导的关键因子和肿瘤 ... - X-MOL
FRA-1的表达水平与肿瘤细胞增殖、凋亡、转化、迁移和侵袭等过程密切相关，是许多肿瘤潜在的治疗靶点和预后因素。 阐明FRA-1的详细作用机制可为肿瘤的诊断、治疗和预后提供理论依 …
Fra-1在癌症中的作用及相关信号通路的研究进展-【维普期刊官网 …
摘要 在激活蛋白1 (activator protein 1,AP-1)二聚体复合物转录因子家族的FOS亚家族成员中,由FOSL1基因编码的转录因子Fra-1对人类肿瘤的转移和进展起到至关重要的作用。 Fra-1在大 …
FRA-1 as a driver of tumour heterogeneity: a nexus between
Nov 10, 2014 · In this review, we examine a growing body of work implicating the transcription factor FOS-related antigen 1 (FRA-1) as a central node in tumour cell plasticity networks, and …