Dec 25, 2024 · FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include Combined Pituitary Hormone Deficiencies, Genetic Forms and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Gastrulation and Regulation of beta-cell development.

Apr 11, 2024 · FOXA1 and FOXA2 have much crosstalk in steroid-hormone-associated cancers, for example, signaling pathways, epigenetic modifications, and post-translational modifications. Both FOXA1 and FOXA2...

Mar 1, 2011 · FOXA2 is a gene that plays a crucial role in the development and differentiation of dopamine neurons in the midbrain. It is expressed in the floor plate and is necessary for the specification and continued differentiation of these neurons.

Nov 14, 2022 · We identify that FOXA2 orchestrates prostate cancer adeno-to-neuroendocrine lineage transition and that Foxa2 expression is significantly induced by androgen deprivation. Moreover, Foxa2 knockdown induces the reversal of adeno-to-neuroendocrine transition.

FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including organogenesis and differentiation, glycolipid metabolism, proliferation, migration and invasion, and drug resistance.

Jun 8, 2024 · Overall, our findings underscore the pivotal role of FOXA2 as a pan-plasticity driver that rewires AP-1 to induce the differential transcriptional reprogramming necessary for cancer cell lineage...

Here we investigate the contribution of FOXA2 to coordinating intestinal epithelial cell function using postconfluent Caco2 cells, differentiated into an enterocyte-like model.

Dec 23, 2004 · Here we show that in normal mice, plasma insulin inhibits the forkhead transcription factor Foxa2 by nuclear exclusion and that in the fasted (low insulin) state Foxa2 activates transcriptional...

FOXA2 was shown to regulate the expression of single genes within the intestine, including the apolipoprotein B locus, the gel-forming mucins, and the transcription factors Pax6 and HNF6 (4, 33, 42, 50, 57). Here we use genome-wide mapping of FOXA2 sites by ChIP-seq to reveal the biological processes regulated by this factor in a human ...

FOXA2 controls the anti-oxidant response in FH-deficient cells. FOXA2 suppresses PKM2 transcription and affects the Wnt/beta-catenin activity to block aerobic glycolysis in thyroid carcinoma. FOXA2 plays a critical role in hepatocellular carcinoma progression and lenvatinib-associated drug resistance.

Apr 11, 2024 · This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential strategies for targeting FOXA1 and FOXA2 for cancer therapy.

Feb 8, 2025 · Title: FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma. FOXA2 suppresses gallbladder carcinoma cell migration, invasion, and epithelial-mesenchymal transition by targeting SERPINB5.

Apr 11, 2024 · FOXA1 and FOXA2 have much crosstalk in steroid-hormone-associated cancers, for example, signaling pathways, epigenetic modifications, and post-translational modifications. Both FOXA1 and FOXA2 are involved in cancer resistance, and targeting FOXA1 and FOXA2 can solve the problem of drug resistance.

Mar 12, 2025 · Foxa2 f/f and Foxa2 f/f Ltf Cre/+ mice were housed in the animal care facility at Cincinnati Children’s Hospital Medical Center according to the National Institute of Health and institutional ...

Feb 7, 2008 · Foxa2 Regulates the Specification, Neurogenesis, and Differentiation of DA Neurons in the Midbrain Floor Plate. Dopaminergic neurons are born in the ventricular zone (VZ) of the midbrain floor plate from proliferative progenitors, initially Neuroepithelial cells (NE) and subsequently radial glia (RG).

Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and is a critical regulator of postnatal uterine gland differentiation in mice.

Aug 16, 2022 · Overexpression of FOXA2 reversed the defective phenotypes and improved hepatocyte functionality in iPSC-derived hepatic cells lacking FOXA2.

Foxa2 is a pioneer TF that can open compact chromatin and allows binding of cis-regulatory elements (CREs) for other TFs in a higher-order gene regulatory network (Burtscher et al., 2013). Foxa2 expression can be detected in all pancreatic progenitor cells at …

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and ...

Jun 9, 2010 · Foxa1 and Foxa2 play both redundant and distinct roles in early pancreas development. We demonstrate here that inducible ablation of both transcription factors in mature mouse β-cells leads to impaired glucose homeostasis and insulin secretion.