Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer.

2024年12月25日 · FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include Combined Pituitary Hormone Deficiencies, Genetic Forms and Hyperinsulinemic Hypoglycemia, Familial, 1. Among its related pathways are Gastrulation and Regulation of beta-cell development.

2024年4月11日 · FOXA1 and FOXA2 have much crosstalk in steroid-hormone-associated cancers, for example, signaling pathways, epigenetic modifications, and post-translational modifications. Both FOXA1 and FOXA2...

2011年3月1日 · FOXA2 is a gene that plays a crucial role in the development and differentiation of dopamine neurons in the midbrain. It is expressed in the floor plate and is necessary for the specification and continued differentiation of these neurons.

2004年12月23日 · Here we show that in normal mice, plasma insulin inhibits the forkhead transcription factor Foxa2 by nuclear exclusion and that in the fasted (low insulin) state Foxa2 activates transcriptional...

FOXA2 was shown to regulate the expression of single genes within the intestine, including the apolipoprotein B locus, the gel-forming mucins, and the transcription factors Pax6 and HNF6 (4, 33, 42, 50, 57). Here we use genome-wide mapping of FOXA2 sites by ChIP-seq to reveal the biological processes regulated by this factor in a human ...

FOXA2 controls the anti-oxidant response in FH-deficient cells. FOXA2 suppresses PKM2 transcription and affects the Wnt/beta-catenin activity to block aerobic glycolysis in thyroid carcinoma. FOXA2 plays a critical role in hepatocellular carcinoma progression and lenvatinib-associated drug resistance.

Here we investigate the contribution of FOXA2 to coordinating intestinal epithelial cell function using postconfluent Caco2 cells, differentiated into an enterocyte-like model.

2024年4月11日 · This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential strategies for targeting FOXA1 and FOXA2 for cancer therapy.

2006年1月1日 · Foxa2—a forkhead transcription factor—controls hepatic lipid metabolism in fasting and type 2 diabetes, improving insulin resistance in peripheral tissues. Insulin resistance—a state of...