Protein fosB, also known as FosB and G0/G1 switch regulatory protein 3 (G0S3), is a protein that in humans is encoded by the FBJ murine osteosarcoma viral oncogene homolog B (FOSB) gene. [5] [6] [7] The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2.

2024年12月25日 · FOSB (FosB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSB include Pseudomyogenic Hemangioendothelioma and Osteoblastoma. Among its related pathways are IL-1 Family Signaling Pathways and ESR-mediated signaling.

The transcription factor ΔFosB, a truncated splice isoform of FosB, accumulates in brain after several types of chronic stimulation. This accumulation is thought to be mediated by the unique stability of ΔFosB compared to all other Fos family proteins.

The fosB gene produces two protein products through alternative splicing: full-length FosB (45 kDa) plus ΔFosB (∼35 kDa) that lacks the C terminal of the full-length form. By the use of antibodies directed against the N and C terminals of FosB, we found that the chronic FRAs are recognized by the N-terminal antibody only (data not shown).

In this review, we provide an overview of FOS and FOSB, including their functions and the differences between lesions with known FOS/FOSB gene rearrangements. Additionally, we discuss the use of FOS / FOSB immunohistochemistry as a diagnostic tool for these lesions.

2011年9月1日 · The fosB gene is an attractive candidate for regulating stress responses, because ΔFosB, an alternative splice product of the fosB gene, accumulates after repeated stress or antidepressant treatments.

2015年4月15日 · ΔFosB is a member of the Fos family of transcription factors. While other family members are induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that it accumulates in response to repeated …

FOSB is a highly sensitive and diagnostically useful marker for pseudomyogenic hemangioendothelioma. our findings show that DeltaFosB increases the expression of MMP-9 and exhibits a significantly high survival and proliferation in MCF-7 cells.

2005年11月1日 · The Fos family of transcription factors includes c-Fos (the human homolog of the retroviral oncogene v-Fos), FosB, Fra-1 and Fra-2 as well as smaller FosB splice variants FosB2 and deltaFosB2.

2022年4月16日 · ΔFosB is a member of the Fos family of transcription factors. While other family members are induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that it accumulates in response to repeated …