Flunarizine, sold under the brand name Sibelium among others, is a drug classified as a calcium antagonist which is used for various indications. [1] It is not available by prescription in the United States or Japan. The drug was discovered at Janssen Pharmaceutica (R14950) in 1968.

2021年12月20日 · Flunarizine is tablet classified as a calcium channel blocker that works to prevent migraine headaches. It also improves the flow of blood and can lower the severity of a migraine. It prevents dizziness and infections of the inner ear and brain.

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel.

2024年11月8日 · Flunarizine (Sibelium) generic is a calcium channel blocker, prescribed for migraine occlusive peripheral vascular disease, vertigo of central and peripheral origin and as an adjuvant in the...

2021年10月20日 · Flunarizine is a medicine used to prevent migraine headaches. Migraine is a medical condition characterised by intense throbbing pain or a pulsating feeling on one side of the head. This medicine helps to reduce the severity of the …

Flunarizine is effective in reducing attack in all forms of migraine but is particularly effective in migraine with severe and disabling neurological symptoms (for instance, migraine with aura or one-sided weakness) with dizziness or vertigo.

Flunarizine is a type of drug known as a calcium channel blocker. Calcium channel blockers are medicines that are most often used to reduce blood pressure or treat certain heart conditions. Flunarizine is not licensed in the UK, and so its use for preventing migraine is 'unlicensed'.