Dec 25, 2024 · FLI1 (Fli-1 Proto-Oncogene, ETS Transcription Factor) is a Protein Coding gene. Diseases associated with FLI1 include Bleeding Disorder, Platelet-Type, 21 and Isolated Delta-Storage Pool Disease. Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development.

FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma through TIE1-mediated PI3K/AKT signaling pathway. FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Fli1 and Tissue Fibrosis in Various Diseases.

Mar 4, 2021 · We developed an in vivo T cell CRISPR screening platform and identified a key mechanism restraining T EFF biology through the ETS family TF, Fli1. Genetic deletion of Fli1 enhanced T EFF responses without compromising memory or exhaustion precursors.

Jan 4, 2025 · Title: FLI1 is associated with regulation of DNA methylation and megakaryocytic differentiation in FPDMM caused by a RUNX1 transactivation domain mutation. An intricate regulatory circuit between FLI1 and GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic differentiation.

Fli1 hyperexpression leads to malignant transformation of cells and progression of cancers such as Ewing’s sarcoma. Deficiency in Fli1 is implicated in the development of systemic sclerosis and hypertensive disorders, which are often accompanied by pronounced fibrosis in different organs.

FLI-1, a member of the E26 transformation-specific (ETS) family of transcription factors, is expressed primarily in hematopoietic cells, including most cells active in immunity, and is involved in immune cell development, maintaining immune homeostasis [1].

Feb 28, 2022 · Here, we review the historical context and latest research on Fli-1, focusing on its role in hematopoiesis, immune response, and malignant transformation. The importance of identifying Fli-1 modulators (both agonists and antagonists) and …

Emerging evidence has shown that Fli1 is implicated in the etiology of several autoimmune diseases, including systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). In this review, we mainly discuss the current evidence for the role of Fli1 in these diseases.

Fli1 (Friend leukemia integration 1), a member of the Ets family of transcription factors, plays critical roles in vascular morphogenesis and homeostasis at mid-gestation, the developmental stage at which expression of its upstream regulator, Etv2, ceases.

The FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Learn about this gene and related health conditions.