2024年12月25日 · FKBP1B (FKBP Prolyl Isomerase 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Ventricular Tachycardia, Familial. Among its related pathways are Cardiac conduction and Ion channel transport.

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene. [5][6] The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.

FKBP1B gene is involved in the genetic susceptibility to the AITDs development in the studied family. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure.

2024年3月5日 · results suggest that both FKBP12.6 and FKBP12 play critical roles in regulating RyR2 function by facilitating the termination of SOICR. Title: FKBPs facilitate the termination of spontaneous Ca2+ release in wild-type RyR2 but not CPVT mutant RyR2.

FKBP 脯氨酰异构酶 1B： 该基因编码的蛋白质是免疫亲和蛋白家族的成员，它在免疫调节和涉及蛋白质折叠和运输的基本细胞过程中发挥作用。这种编码的蛋白质是一种顺反式脯氨酰异构酶，可结合免疫抑制剂 FK506 和雷帕霉素。它与 FK506 结合蛋白 1A 高度相似。它的生理学作用被认为是在心肌的兴奋 ...

2025年2月8日 · FKBP12.6 plays protective role in cardiac hypertrophy through inhibiting Ca (2+) /calmodulin-mediated signalling pathways. The heart contraction is controlled by the Ca2+-induced Ca2+ release between L-type Ca2+ channels and ryanodine receptors. RyRs became more sensitive to Ca2+ triggers without FKBP12.6, leading to ventricular arrthymias.

2016年9月14日 · The protein encoded by the FKBP1B gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin.

与人类FKBP1B（FKBP脯氨酸异构酶1B）正交。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 A tissue-specific atlas of mouse protein phosphorylation and expression. Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.

Through continuous exploration, FKBP1B has been found to be able to control Ca 2 + release by binding to RyR2 receptors in both myocardium and brain tissue. This article reviews FKBP1B’s functions and regulatory mechanisms in heart and brain tissue in order to provide a theoretical basis for understanding the physiological and pathological ...

Located in sarcoplasmic reticulum membrane. Part of Calcium Channel complex. Is expressed in nervous system and testis. Used to study catecholaminergic polymorphic ventricular tachycardia. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).