Mitochondrial fission 1 protein (FIS1) is a protein that in humans is encoded by the FIS1 gene on chromosome 7. [5][6][7] This protein is a component of a mitochondrial complex, the ARCosome, that promotes mitochondrial fission. [7][8] Its role in mitochondrial fission thus implicates it in the regulation of mitochondrial morphology, the cell ...

2021年5月13日 · DRP1可以通过不同的方式被激活来驱动哺乳动物的线粒体分裂。 这些方式包括：与线粒体DRP1受体（MFF、MID49、MID51和FIS1）相互作用；DRP1修饰（翻译后修饰）；与肌动蛋白细胞骨架（肌动蛋白丝）或线粒体脂质心磷脂相互作用；以及与各种细胞器接触，包括内质网（ER）、溶酶体和高尔基（以高尔基衍生囊泡的形式）。 目前尚不清楚这些因素是导致单一的分裂途径还是不同的分裂途径。 这些作者利用超分辨率显微镜对线粒体分裂进行了仔细分 …

Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for mitochondrial division or fission and subsequently determined to mediate human mitochondrial and peroxisomal fission. Yet, its exact functions in humans, ...

2025年1月16日 · Drp1和Fis1是线粒体分裂过程中的两个关键调控因子。 Drp1是一种动力相关蛋白，它定位于线粒体外膜上，通过形成螺旋状结构来介导线粒体的分裂。

2024年11月20日 · FIS1（Fission 1）主要位于线粒体外膜上，是介导线粒体分裂的关键蛋白，也被确认是凋亡和线粒体自噬途径的重要组成部分。 MFF和FIS1通过与DRP1（Dynamin-Related Protein 1）结合促进其在线粒体膜上的聚集和活性，随后通过GTP水解驱动线粒体膜的分裂。

2024年12月25日 · FIS1 (Fission, Mitochondrial 1) is a Protein Coding gene. Diseases associated with FIS1 include Spinocerebellar Ataxia 12 and Cranial Nerve Disease. Among its related pathways are Peroxisomal lipid metabolism and CAMKK2 pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

通过药物抑制DRP1或 Fis1 或者过表达Mfn1可以导致线粒体延长，从而降低对凋亡刺激的敏感性。 相比之下，通过 MFN2 降解、OPA1敲低或Fis1和DRP1过表达形成的线粒体碎片能够显著增强对凋亡刺激的敏感性。

2022年4月27日 · In human FIS1, NMR and X-ray structures show different arm conformations, but its importance for human DRP1 recruitment is unknown. Here, we use molecular dynamics simulations and comparisons to experimental NMR chemical shifts to show the human FIS1 arm can adopt an intramolecular conformation akin to that observed with yeast Fis1p.

2021年12月1日 · Fis1 pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein-1 (Drp1) to mitochondria. Fragmented mitochondria fueled actin filament...

Enables identical protein binding activity. Involved in several processes, including cellular response to thapsigargin; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrion and peroxisomal membrane. Is integral component of mitochondrial outer membrane.