Filamin A, encoded by the FLNA gene, is a widely expressed filamin that regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. [7]

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration.

2024年12月25日 · FLNA (Filamin A) is a Protein Coding gene. Diseases associated with FLNA include Melnick-Needles Syndrome and Otopalatodigital Syndrome, Type Ii. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by Rho GTPases.

The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. Learn about this gene and related health conditions.

Filamins are a class of proteins that hold two actin filaments at large angles. [1] . Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 immunoglobulin-like repeat modules of roughly 95 amino acids. There are two hinge regions; between repeats 15-16 and 23-24.

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration.

2012年4月1日 · Filamin A [formerly known as actin-binding protein 280 (ABP280)] is a non-muscle actin filament cross-linking protein first identified in macrophages in 1975. 1 Since then, three isoforms of filamins, known as filamin A, B and C, which are products of distinct genes have been identified in different mammalian epithelia. 2, 3 Studies from the ...