Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. [5] [6] It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein.

2022年1月17日 · Zhittya Genesis Medicine plans to launch what it is calling a “Compassionate Use Clinical Trial” of FGF-1, a biological compound aiming to stimulate new blood vessel growth in the brain, for people with mild-to-moderately severe Parkinson’s disease.

2024年12月25日 · FGF1 (Fibroblast Growth Factor 1) is a Protein Coding gene. Diseases associated with FGF1 include Common Peroneal Nerve Lesion and Overnutrition. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

FGF1 has some therapeutic potential for cardiovascular disorders. Phase I trials have shown that intramyocardial injection of FGF1 during coronary artery bypass graft surgery improves collateral artery growth and capillary proliferation 85 .

2020年9月2日 · Fibroblast growth factors (FGFs) are broad-spectrum mitogens and regulate a wide range of cellular functions, including migration, proliferation, differentiation, and survival. It is well...

Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor.

FGF1 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. FGF1 is implicated in the occurrence of cleft palate.

FGFRL1, with structural similarity to FGFRs, is a membrane protein of ∼500 amino acids with three extracellular immunoglobulin-like domains (I, II, and III), a transmembrane domain (TM), and a short intracellular tail with no tyrosine kinase domain. SP indicates a cleavable secreted signal sequence. Table 2.

2025年2月8日 · Title: Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis.

2022年6月9日 · Here, we provide an overview of the known metabolic functions of endogenous FGF1 and discuss its therapeutic potential, distinguishing between peripherally or centrally administered FGF1.