Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein that in humans is encoded (i.e., its formation is directed) by the FFAR4 gene. [5] . This gene is located on the long (i.e. "q") arm of chromosome 10 …

2024年12月25日 · FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Body Mass Index Quantitative Trait Locus 10 and Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome. Among its related pathways are GPCR downstream signalling and Incretin synthesis, secretion, and inactivation.

2021年8月1日 · Free fatty acid receptor 4 (FFAR4), also known as G protein-coupled receptor 120, is a long-chain fatty acid receptor highly expressed in adipocytes, endothelial cells, and macrophages. Activation of FFAR4 helps maintain metabolic homeostasis by regulating adipogenesis, insulin sensitivity, and inflammation.

2022年11月30日 · These findings highlight the original role of tubular FFAR4 in cellular senescence via AMPK/SirT3 signaling and identify FFAR4 as a potential drug target against AKI.

In this work, we will specifically focus on the function of the FFAR4 receptor and its recently recognized importance in regulating inflammatory mechanisms, in particular on its anti-atherosclerotic potential in the context of an inflammatory theory of atherosclerosis.

2023年6月7日 · FFAR4 plays crucial roles in maintaining metabolic homeostasis via regulating adipogenesis, insulin sensitivity and inflammation, and is a highly valuable target for treating metabolic...

2025年3月6日 · FFAR4 (free fatty acid receptor 4) has emerged as a target for preventing cardiovascular disease through its ability to control macrophage inflammation and foam cell formation. Previous studies have shown that FFAR4 activation can protect against the accumulation of arterial plaque buildup in atherosclerotic animal models.

2025年2月8日 · GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease. Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus. Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.

2025年1月13日 · Here we show that the expression of free fatty acid receptor Ffar4, a receptor for long-chain fatty acids, is decreased in patients and mouse models with diabetes, which is associated with...

6 天之前 · This conversion may lead to a state in which the resulting compounds do not interact with GCPRs for LCFAs (GPR40/FFAR1 and GPR120/FFAR4) but exert biological effects through receptors for SCFAs (GPR41 and GPR43) and MCFAs (GPR84) [68,69,70,71]. Controlling the LCFA conversion process in vivo is a major challenge, which makes the results of ...